计算机工程与应用2016，Vol.52Issue(15)：60-64,140,6.DOI:10.3778/j.issn.1002-8331.1604-0019
三元统计语言模型对基因表达载体设计的优化
3-gram statistical language model optimization to expression vector design.
摘要
Abstract
By assembling BioBrick according to a standard, complex genetic constructs composed of dozens of functional blocks can be made. But usually every category of BioBrick contains a few or many parts. With the increasing of Bio-Brick amount, the process of assembling more than a few of sets of BioBrick can be costly, time consuming and error prone. At the last step of assembling it is quite difficult to make decision which part should be selected. Based on statisti-cal language model, a dynamic programming algorithm is carried out to solve the problem. The algorithm optimizes the results of a genetic design based on a grammatical model and figures out an optimal solution. In this way, redundant opera-tions can be reduced and the time and cost required for conducting biological experiment can be minimized.关键词
合成生物学/统计语言模型/动态规划算法/合成生物学标准“零件”Key words
synthetic biology/statistical language model/dynamic programming/BioBrick分类
计算机与自动化引用本文复制引用
方刚,张社民..三元统计语言模型对基因表达载体设计的优化[J].计算机工程与应用,2016,52(15):60-64,140,6.基金项目
国家自然科学基金（No.61173113）。 （）
