军事医学2016，Vol.40Issue(7)：564-568,5.DOI:10.7644/j.issn.1674-9960.2016.07.008
含银海藻酸盐敷料理化性质及其抗菌性能的研究
Physico-chemical properties and antimicrobial activity of silver ion dressings
李小军 1顾其胜 2王庆生 3李俊杰 4张琪5
作者信息
- 1. 武警总医院，北京 100039
- 2. 军事医学科学院基础医学研究所，北京 100850
- 3. 厦门海沧口腔诊所，福建厦门 361026
- 4. 上海其胜生物材料技术研究所，上海 200621
- 5. 山东颐诺生物科技有限公司，山东滨州 256500
- 折叠
摘要
Abstract
Objective To detect the physico-chemical properties , cytotoxicity and antimicrobial activity of dressings containing Ag +.Methods The morphology of this dressing was shown by the scanning electron microscope ( SEM ) .The cytotoxicity was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method.Using the shake flask test method , the antibacterial effect of dressings was studied .Result There was no significant difference in the water vapor transmission rate between the dressings (P>0.05).Compared with the alginate calcium dressing ,silver ion dressings had a stronger swelling rate .A higher ion concentration would lead to a much larger swelling rate and slower degradation . A lower cytotoxicity was exhibited among the dressings .The silver ion dressing had stronger bacteriostasis to Gram-positive ( G+) and Gram-negative ( G-) bacteria than the alginate calcium dressing .Conclusion The experiment has proved that the silver ion dressing has stronger antibacterial activity and lower cytotoxicity , and it is more effective for wound surface healing, with a shortened treatment course .关键词
生物敷料/银离子/海藻/细胞毒性/抗菌活性/显微镜检查,电子,扫描Key words
biological dressings/silver ion/seaweed/cytotoxicity/antimicrobial activity/microscopy, electron, scanning分类
医药卫生引用本文复制引用
李小军,顾其胜,王庆生,李俊杰,张琪..含银海藻酸盐敷料理化性质及其抗菌性能的研究[J].军事医学,2016,40(7):564-568,5.
