度洛西汀与舍曲林治疗老年抑郁症的对照研究OA
Control Study of Duloxetine and Sertraline in the Treatment of Geriatric Depression
目的：评价度洛西汀和舍曲林治疗老年抑郁症的临床疗效及安全性。方法采用随机分组对照方法，将55例患者随机分为度洛西汀及舍曲林组并接受相应药物治疗8周。两组分别在治疗后第2、4、8周末，用汉密尔顿抑郁量表（HAMD）评估疗效，用治疗副反应量表（TESS），结合心电图、血生化及生命体征评估治疗的安全性。结果经过8周治疗，两组的有效率相当，不良反应发生率差异有统计学意义。结论度洛西汀对老年抑郁症的疗效与舍曲林相当，并且安全性更好。
Objective To evalue the efficacy and safety of duloxetine and sertraline in treatment of geriatric depression(GD). Methods In this randomized double-blind trial. 55 GD patients were divided into duloxetine group and sertraline group for eight-week treatment. All patients were assessed for efficacy by HAMA and the safety by TESS together with ECG, blood chemistry and vital signs after 2, 4, 8 weeks treatments. Results After 8 weeks of treatment, both groups w…查看全部>>
吴彦清
天津市安定医院老年科 C9 区，天津 300222
医药卫生
老年抑郁症度洛西汀舍曲林
Geriatric depressionDuloxetineSertraline
《继续医学教育》 2016 (7)
158-160,3
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