检验医学与临床2016，Vol.13Issue(13)：1772-1773,1777,3.DOI:10.3969/j.issn.1672-9455.2016.13.011
脑脊液磷酸化 tau蛋白在阿尔茨海默病诊断中的应用
Study on the diagnostic value of phosphorylated tau protein in the patients with Alzheimer′s disease
摘要
Abstract
Objective To study the diagnostic value of phosphorylated tau (p‐tau) protein in the patients with Alzheimer′s dis‐ease (AD) .Methods The level of p‐tau protein was measured by ELISA in 51 patients with AD ,52 patients with vascular dementia (VD) and 50 controls ,respectively .The levels of p‐tau protein were compared among groups .Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of p‐tau protein in patients with AD .And the cut‐off value ,sensitivity and specificity were calculated .Results The median and the quantile interval (P25 - P75 ) level of p‐tau protein in AD group ,VD group and control group were 76 .3 (59 .1-89 .8)ng/L ,36 .4 (28 .3-44 .2)ng/L and 34 .9 (27 .7-41 .6)ng/L ,respectively .The level of p‐tau protein of AD group was significantly higher than that of VD and control group (P<0 .01) .The level of p‐tau protein of VD group was higher than control group ,but no significant difference was found (P=0 .326) .The area under curve (AUC) was 0 .944 (95% CI:0 .904 -0 .985) .The cut‐off value for detection of p‐tau protein was 55 .5 ng/L .The sensitivity and specificity were 82 .4% and 96 .1% ,respectively .Conclusion The level of p‐tau protein has increased specifically in patients with AD ,and it can serve as a biomarker for diagnosis of AD .关键词
磷酸化tau蛋白/阿尔茨海默病/诊断Key words
phosphorylated tau protein/Alzheimer′s disease/diagnosis引用本文复制引用
罗庆新,罗星星,陈家强,蓝燕玲,朱嫦琳,李炜煊..脑脊液磷酸化 tau蛋白在阿尔茨海默病诊断中的应用[J].检验医学与临床,2016,13(13):1772-1773,1777,3.基金项目
佛山市卫生和计生局医学科研课题项目（20160138）。 （）
