检验医学与临床2016，Vol.13Issue(14)：1914-1916,3.DOI:10.3969/j.issn.1672-9455.2016.14.004
便秘型肠易激综合征患者的血浆5-HT 水平与氧化应激作用的相关性分析
The correlation of plasma 5-HT expression and oxidative stress in patients with constipation-predominant irritable bowel syndrome
摘要
Abstract
Objective To analyze the correlation of plasma 5‐hydroxytryptamine (5‐HT ) expression and oxidative stress in pa‐tients with constipation‐predominant irritable bowel syndrome .Methods A total of 78 patients with constipation‐predominant irri‐table bowel syndrome were selected as the observation group ,and 78 healthy people were chosen as the control group at the same period .5‐HT ,lipid peroxide (LPO) and malondialdehyde (MDA) were detected as well as fasting blood‐glucose (FBG) ,triglyceride (TG) ,low density lipoprotein cholesterol (LDL‐C) and high density lipoprotein cholesterol (HDL‐C) .The correlation was analyzed by Partial correlation analysis and Logistic regression analysis .Results The level of MDA (4 .46 ± 0 .51)nmol/L and LPO(1 .68 ± 0 .38)nmol/L in the observation group were higher than that of the control group (P<0 .05) .The level of 5‐HT in the observation group (1 828 .44 ± 300 .87)pg/mL was also found to be significantly higher than that of control group (1 236 .93 ± 289 .48)pg/mL (P<0 .05) .Partial correlation analysis showed that the level of 5‐HT were positively correlated with MDA (r=0 .325 ,P<0 .05) , LPO(r=0 .432 ,P<0 .05) and TC(r=0 .357 ,P<0 .05) in the patients with constipation‐predominant irritable bowel syndrome . However ,level of 5‐HT were negatively correlated with HDL‐C(r= -0 .385 ,P<0 .05) .Logistic regression analysis showed that MDA ,LPO ,TC and HDL‐C were the independent risk factors of the 5‐HT(P<0 .05) .Conclusion Patients with constipation‐pre‐dominant irritable bowel syndrome has over expression levels of 5‐HT accompanied with over expression of MDA and LPO .In addi‐tion ,the expression of MDA and LPO can affect the expression of 5‐HT ,which may be the mechanism of pathophysiology in the constipation‐predominant irritable bowel syndrome .关键词
便秘型肠易激综合征/5-羟色胺/氧化应激作用/相关性/丙二醛Key words
constipation-predominant irritable bowel syndrome/5-hydroxytryptamine/oxidative stress/correlation/ma-londialdehyde引用本文复制引用
史盛梅,韩文,袁东红,温彦丽,王会丰,冯义朝,孟存英,戴光荣,刘磊..便秘型肠易激综合征患者的血浆5-HT 水平与氧化应激作用的相关性分析[J].检验医学与临床,2016,13(14):1914-1916,3.基金项目
河北省2013年医学科学研究课题（20130249）。 （）
