检验医学与临床2016，Vol.13Issue(14)：1922-1923,1926,3.DOI:10.3969/j.issn.1672-9455.2016.14.007
糖化白蛋白、糖化血红蛋白及其比值在新诊断2型糖尿病患者降糖过程中的变化
Changes of the glycated albumin,glycated haemoglobin,and their ratio in newly diagnosed patients with type 2 diabetes
摘要
Abstract
Objective To explore the changes of the glycated albumin (GA ) ,glycated haemoglobin (HbA1c) ,and their ratio (GA/HbA1c) in newly diagnosed patients with type 2 diabetes mellitus (T2DM ) .Methods Seventy inpatients and outpatients with newly diagnosed T2DM in the hospital were selected .All the patients were treated with metformin for 24 weeks .GA and HbA1c were measured before treatment and every four weeks after treatment .Results The level of GA decreased from (26 .1 ± 8 .3)% at baseline to the lowest value [(17 .3 ± 4 .5)% ] at eighth week after treatment ,the difference had statistical significance (P<0 .01) ,and the level of HbA1c decreased from (10 .1 ± 2 .4)% at baseline to (7 .5 ± 1 .0)% at 16th week ,the difference was statistically significant (P<0 .01) .The level of GA/HbA1c decreased from (2 .58 ± 0 .35) at baseline to the (2 .06 ± 0 .24) at eighth week ,however ,the ratio increased from (2 .06 ± 0 .24) at eighth week to (2 .31 ± 0 .31) at 16th week ,the differences were all statistically significant (P<0 .001) .Although the GA/HbA1c ratio at 16th week and 24th were significantly lower than that at baseline (P<0 .01) .The change of the GA/HbA1c ratio during 24 weeks (△GA/HbA1c) was negatively correlated with both HbA1c (r= -0 .657 ,P=0 .008) and GA (r= -0 .702 ,P=0 .002) at baseline .Moreover ,the △GA/HbA1c was positively correla‐ted with △GA (r=0 .813 ,P<0 .001) during 24 weeks ,but △GA/HbA1c was not correlated with △HbA1c .Conclusion In newly diagnosed patients with T2DM ,the GA/HbA1c ratio may be better than GA or HbA1c in reflecting the effect of hypoglycemic when the patients are treated with metformin .关键词
糖化白蛋白/糖化血红蛋白/2型糖尿病Key words
glycated albumin/glycated haemoglobin/type 2 diabetes mellitus引用本文复制引用
龚永慧,冯玉丽,曾学辉,张春雷,谢斯雅..糖化白蛋白、糖化血红蛋白及其比值在新诊断2型糖尿病患者降糖过程中的变化[J].检验医学与临床,2016,13(14):1922-1923,1926,3.基金项目
深圳市卫生计生系统科研项目（201303086）。 （）
