检验医学与临床2016，Vol.13Issue(14)：1924-1926,3.DOI:10.3969/j.issn.1672-9455.2016.14.008
育龄女性MTHFR基因多态性与叶酸浓度的关系研究
Study on the relationship between the MTHFR gene polymorphism of fertile women and the concentration of folic acid
摘要
Abstract
Objective To explore the correlation of MTHFR C677T gene polymorphism and the concentrations of folic acid in fertile women .Methods Gene chip method was used to examine the polymorphism ,and all the women were given oral administra‐tion of folic acid 800μg/d for one month .5 mL anticoagulant blood from the fertile women were detected before and after giving the oral folic acid .And the level of folic acid in peripheral blood was analyzed by chemiluminescence .Results The detection rate of gene polymorphism of CC ,CT and TT were 26% ,54% and 20% ,respectively .The levels of folic acid in peripheral blood of CC genotype groups before and after giving the oral folic acid had no significant differences (P> 0 .05) ,and the rates in CT and TT genotype groups after giving the oral folic acid were significantly higher than before(P<0 .05) .Conclusion MTHFR C677T genotypes can affect the concentration of folic acid in peripheral blood .And oral folic acid can improve the concentration of folic acid in peripheral blood in fertile women .关键词
亚甲基四氢叶酸还原酶/基因多态性/育龄女性/叶酸Key words
MTHFR/gene polymorphism/fertile women/folic acid引用本文复制引用
杨丰美,迟玉君,张丽萍..育龄女性MTHFR基因多态性与叶酸浓度的关系研究[J].检验医学与临床,2016,13(14):1924-1926,3.基金项目
太和医院院级项目资助（2014JJXM019）。 （）
