杨士军 1陆卫平 2郑云会 1张金华 1刘满庆 1夏永祥3
作者信息
- 1. 南京医科大学附属淮安第一医院 核医学科，江苏淮安223300
- 2. 南京医科大学附属淮安第一医院 内分泌科，江苏淮安223300
- 3. 南京医科大学附属南京医院检验科，南京210006
- 折叠
摘要
Abstract
Objective To analyze the diagnostic value of serum carbohydrate antigen 125 (CA125) ,human epididymis protein 4 (HE4) and ROMA in patients with ovarian cancer .Methods By Electrochemical luminescence (ECLIA) ,serum HE4 and CA125 of 70 cases diagnosed as ovarian benign disease and 137 cases diagnosed as ovarian cancer were detected before treatment .ROMA were calculated and all the data were analyzed statistically .Results The level of CA125 ,HE4 and ROMA of patients with ovarian cancer were 270 .1 U/mL ,287 .1 pmol/L and 71 .5% respectively ,which of patients with benign ovarian diseases were 25 .4 U/mL , 69 .3 pmol/L ,17 .1% and the level of three indicators in the control group were 14 .5 U/mL ,61 .1 pmol/L and 11 .8% .The differ‐ence of HE4 between the group of benign ovarian diseases and the control group had no statistical significance (P>0 .05) .The sen‐sitivity ,specificity ,positive predictive value ,negative predictive value and coincidence of CA 125 were 77 .4% ,74 .3% ,85 .5% , 62 .6% and 76 .3% respectively ,which of HE4 were 79 .6% ,77 .1% ,87 .2% ,65 .8% and 78 .7% respectively and of ROMA were 89 .8% ,88 .6% ,93 .9% ,81 .6% ,and 89 .4% respectively .The area under the curve (AUC) of CA125 ,HE4 and ROMA were 0 .854 ,0 .936 and 0 .954 respectively .AUC of ROMA was higher than HE4 ,and that of HE4 was also higher than CA125 .The difference of AUC of HE4 before and after menopause was little .Conclusion HE4 could eliminate the interference of ovarian be‐nign disease in the diagnosis of ovarian cancer and specificity of HE4 is higher than CA125 .Combined detection of CA125 ,HE4 and ROM A can improve the positive rate of ovarian cancer .关键词
肿瘤标志物/卵巢癌/人附睾蛋白4/ROM A/ROCKey words
tumor markers/ovarian cancer/human epididymis protein 4/ROMA/ROC
