摘要
Abstract
Objective To analyze the correlation of serum follicle‐stimulating hormone(FSH) ,luteinizing hormone(LH) ,estra‐diol(E2 ) and bone metabolic indicators in postmenopausal women ,and to provide the reference for the diagnosis and treatment of osteoporosis .Methods A total of 220 postmenopausal women with osteoporosis from May 2010 to October 2012 were collected . Blood calcium (Ca) ,alkaline phosphatase (ALP) ,parathyroid hormone (PTH) ,β‐Crosslaps (β‐Crossl) ,N‐MID Osteocalcin (N‐Os‐teoc) and total N‐terminal propeptide of type I collagen (TPINP) were detected by Cobas 8000 analyzer ,and FSH ,LH and E2 were measured by DXI‐800 analyzer .Results FSH ,LH and FSH/LH were positively correlated with N‐Osteoc and TPINP(P<0 .05) , meanwhile ,FSH/LH and E2 were also positively correlated with β‐Crossl(P<0 .05) .The correlation coefficient of FSH/LH and TPINP were the highest (r=0 .341) .Multiple linear regression analysis showed that the changes of bone metabolic indicators ex‐plained by effects of serum FSH and FSH/LH accounted for 0 .7% to 6 .6% ,1 .1% to 30 .9% ,respectively .And the percentage of serum FSH/LH which explained the changes of bone metabolic indicators was the highest ,while that of LH was only about 0 .4%to 2 .3% .Logistic regression analysis showed that age ,FSH ,FSH/LH and TPINP were independent risk factors of postmenopausal osteoporosisis .The critical values of FSH and FSH/LH to diagnose postmenopausal osteoporosisis were 46 .36 and 2 .09 ,respec‐tively .Conclusion With the increasing of the levels of bone metabolic indicators ,serum FSH ,LH and FSH/LH levels are also increasing . The combined detection of FSH and FSH/LH has higher value than single indicator in the diagnosis of postmenopausal osteoporosisis .关键词
促卵泡激素/促黄体生成素/雌二醇/骨质疏松Key words
follicle-stimulating hormone/luteinizing hormone/estradiol/osteoporosis
