检验医学与临床2016，Vol.13Issue(14)：1949-1952,4.DOI:10.3969/j.issn.1672-9455.2016.14.017
急性心肌梗死患者急诊PCI术后ST段回落与术前血清NT-proBNP水平的相关性研究
Correlation analysis of ST-segment resolution after PCI and serum NT-proBNP before PCI in patients with acute myocardial infarction
杨晓仪 1张晓坤 1付玉梅 1黎文成 1张立建 1古雅珏1
作者信息
- 1. 广州医科大学附属第三医院北院检验科 510000
- 折叠
摘要
Abstract
Objective To evaluate the correlation of ST‐segment resolution (STR) after percutaneous coronary intervention (PCI) and serum N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) before PCI in patients with acute myocardial infarction (AMI) .Methods One‐hundred and twenty AMI patients were enrolled in this study and divided into two group based on condition of STR of 180 min after PCI treatment :ST‐segment resolution group (group A ,n= 108) and ST‐segment not resolution group (group B ,n=12) .The levels of NT‐proBNP before and 180 min after PCI were tested .The prevalence of major adverse cardiac e‐vents (MACE) one year after PCI were also been recorded .Results The level of NT‐proBNP in group A after PCI treatment [(854 .3 ± 70 .2)pg/mL] was significantly lower than before[(1 064 .3 ± 173 .2)pg/mL](P=0 .031) .After PCI treatment ,the inci‐dence rate of MACE in group A (14 .8% ) was significantly lower than those of group B (50 .0% )(P<0 .05) .For AMI patients , STR were negatively associated with MACE (r= -0 .667 ,P= 0 .005) and levels of △NT‐proBNP were negatively related with MACE(r= -0 .551 ,P=0 .023) while positively associated with STR (r=0 .629 ,P=0 .009) .ROC analysis showed that the AUC of △NT‐proBNP and STR were 0 .838 and 0 .903 ,respectively ,and cut‐off values of △NT‐proBNP and STR were 65 .4 and 33 .5 respectively .The 95% CI of the two indicators were 0 .714 -0 .893 and 0 .834 -0 .953 .The sensitivity and specificity of △NT‐proBNP were 88 .4% and 83 .7% ,which of STR were 83 .4% and 80 .3% ,respectively .Conclusion For AMI patients ,the levels of NT‐proBNP are associated with STR at time point of 180 min after PCI .Both of the indicators are useful for MACE prognosis .关键词
急性心肌梗死/急诊冠脉介入治疗/ST段回落/N末端B型脑钠肽前体Key words
acute myocardial infarction/acute percutaneous coronary intervention/ST-segment resolution/NT-proBNP引用本文复制引用
杨晓仪,张晓坤,付玉梅,黎文成,张立建,古雅珏..急性心肌梗死患者急诊PCI术后ST段回落与术前血清NT-proBNP水平的相关性研究[J].检验医学与临床,2016,13(14):1949-1952,4.
