摘要
Abstract
Objective To study and analyze the theory and preventive measures of acute lung injury caused by paraquat poison‐ing .Methods A total of 26 patients with acute lung injury caused by paraquat poisoning were selected .The basic clinical data ,diag‐nosis and treatment process were analyzed retrospectively .And the pathogenesis of acute lung injury was summarized .Eighteen pa‐tients were divided into control group ,which accepted the general treatment ,the other 8 cases which used the treatment of blood purification ,elimination of oxygen free radicals and immunosuppressant 8 patients were selected as observation group .The curative effects between the two groups were compared .Results The clinical features of the patients with acute lung injury caused by pa‐raquat poisoning were gastrointestinal complaints ,pneumothorax ,subcutaneous emphysema and melena .From the first day after hospitalization to the 3th day ,alanine aminotransferase (ALT) ,total bilirubin (TBIL) ,blood urea nitrogen (BUN) ,serum creati‐nine (Scr) ,creatine kinase‐MB (CK‐MB) and white blood cell (WBC) were increased .While arterial partial pressure of oxygen (PaO2 ) were obviously decreased .All the indexes had been decreased on the day of discharged from hospital except PaO 2 .The mor‐tality rate of observation group (22 .2% ) was significantly lower than that of the control group (75 .0% ) (P<0 .05) .Lung imaging examination showed that most of the patients had interstitial lung disease and lung ground‐glass opacity ,both of the incidence were significantly higher than that of other pathological types (P<0 .05) ,the percentage of these two lesion types were higher than other types .And the percentage of exudative lesion was higher than that of mediastinal lesion and cardiac disease .Conclusion Inflamma‐tion ,oxidative damage and abnormal gene expression are the theory of acute lung injury caused by paraquat poisoning .Vomiting ,en‐ema and gastric lavage combined with blood purification ,removal of oxygen free radicals and immunosuppressant treated on the pa‐tients will help to improve the prognosis of the patients .关键词
百草枯中毒/急性肺损伤/原理/预防Key words
paraquat poisoning/acute lung injury/theory/prevention
