摘要
Abstract
Objective To observe the effect of combination of astragalus injection with recombinant tissue plasminogen activator (rt‐PA) on the result of CT perfusion and the occurrence of hemorrhagic transformation (HT) in acute ischemic stroke patients . Methods A total of 54 patients with acute ischemic stroke clinically confirmed within 6 h were retrospectively analyzed .According to two different treatment ,54 cases were divided into rt‐PA group (n= 24) and astragalus injection combined with rt‐PA group (n=30) .Partial clinical data ,CT perfusion parameters about relative cerebral blood flow (rCBF) ,relative cerebral blood volume (rCBV) ,relative permeability surface (rPS) and NIHSS scores before and after thrombolytic therapy within 24 h were collected . The number of HT cases occurred in two weeks was also recorded .Then the clinical data ,the baseline NIHSS scores ,the change of the rCBF ,rCBV ,rPS ,NIHSS scores and the incidence rate of HT were compared between the two groups .Results There was no significant difference in clinical data and the base NIHSS scores before the treatment between the two groups (P>0 .05) .After treatment ,the change of rCBF ,rCBV ,rPS and NIHSS scores in astragalus injection combined with rt‐PA group were significantly higher than that of rt‐PA group (P<0 .05) .While there was no difference in the incidence rate of HT between two groups (P>0 .05) .Conclusion Astragalus injection combined with rt‐PA can improve the cerebral blood supply of the patients with acute is‐chemic stroke ,meanwhile it can reduce permeability of cerebral vascular surface ,which consequently improve the prognosis .关键词
脑卒中/黄芪/重组组织型纤溶酶原激活剂/静脉溶栓Key words
stroke/astragalus/recombinant tissue plasminogen activator/intravenous thrombolysis
