摘要
Abstract
Objective To explore the relationship between chromosomal abnormalities ,chromosome polymorphism and chromo‐some karyotype in patients with abnormal fertility and to direct aristogenesis and good brood .Methods A total of 1 465 couples with abnormal fertility who admitted in the hospital during 2013 to 2015 were given the peripheral blood culture ,cell harvest ,pro‐ducer and G banding and karyotype analysis .Results Detection rate of chromosome abnormality in 1 465 couples was 5 .19% , which of male (1 .84% ) was lower than that of female (3 .34% ) ,and the difference was statistically significant (P<0 .05) .In the patients with abnormal fertility ,the detection rate of chromosome abnormality in individuals with early abortion was the highest (11 .74% ) ,followed by the ones with birth defects (8 .00% ) ,which were higher than the other situations ,the differences was sta‐tistically significant ( P < 0 .05 ) .Meanwhile ,the detection rate of chromosome polymorphism was 11 .74% ,which of male (10 .85% ) was higher than that of female (0 .89% ) ,and the difference was statistically significant (P<0 .05) .The detection rate of stillbirth (14 .52% ) and premature birth (12 .68% ) were higher than other situations ,and the differences was statistically signifi‐cant (P<0 .05) .Conclusion Chromosomal abnormalities and chromosome polymorphism could lead to the occurrence of abnormal fertili‐ty .So the chromosome karyotype analysis should be treated as a routine inspection of optimal fertility project to direct good birth .关键词
染色体异常/染色体多态变异/不良生育/染色体核型Key words
chromosomal abnormalities/chromosome polymorphism variation/abnormal fertility/chromosome karyotype
