昆明医科大学学报2016，Vol.37Issue(6)：48-51,4.
CDH13基因变异与非小细胞肺癌的相关性
The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer
摘要
Abstract
Objective To evaluate the correlation of the single nucleotide polymorphisms (SNPs) in CDH13 with non-small cell lung cancer (NSCLC) . Methods 115 patients with NSCLC and 110 healthy controls were included in present study. Two SNPs (rs11646213 and rs7195409) in CDH13 were genotyped using TaqMan method. The association of these two SNPs with NSCLC was calculated and assessed. Results The genotypic and allelic frequencies of rs11646213 showed significant difference between NSCLC patients and the control group (P<0.05), (OR=0.464, 95% CI:0.273~0.789) . The genotypic and allelic frequencies of rs7195409 showed significant difference between the stage I+II and stage III+IV groups (P<0.05), (OR=0.491, 95% CI:0.243~0.991) . Conclusions The rs16146213 has a strong association with NSCLC and G allelic showed a protective effect. The rs7195409 has a strong association between stage I+II and III+IV in NSCLC, and G allele may play a protective role in the development of NSCLC.关键词
非小细胞肺癌/CDH13/单核苷酸多态性Key words
Non-small cell lung cancer/CDH13/Single-nucleotide polymorphisms分类
医药卫生引用本文复制引用
洪超,李盈甫,马千里,蔡秋龙,姚宇峰,俞建昆,廖国阳..CDH13基因变异与非小细胞肺癌的相关性[J].昆明医科大学学报,2016,37(6):48-51,4.基金项目
云南省卫生科技计划项目（2014NS193）；云南省应用基础研究基金资助项目（2012FB064）；高等学校博士学科点专项科研基金资助项目 （）
