岭南现代临床外科2016，Vol.16Issue(4)：396-401,6.DOI:10.3969/j.issn.1009-976X.2016.04.006
DNA损伤修复基因XRCC1 Arg194Trp 基因多态性与中国人群结直肠癌易感性的Meta分析
Meta -analysis of the correlation between XRCC1 Arg194Trp polymorphism and genetic susceptibility of colorectal cancer
黄盛鑫 1周军 2李英儒 2彭启全 1谢锷 1王小忠1
作者信息
- 1. 515000 广东汕头 汕头市中心医院 中山大学附属汕头医院 普外一科
- 2. 510120 广州 中山大学孙逸仙纪念医院胃肠外科
- 折叠
摘要
Abstract
Objective To explore the relationship between the polymorphism of X-ray cross complementing group 1 (XRCC1) Arg194Trp and genetic susceptibility of colorectal cancer (CRC). Methods All eligible case-control studies on the relationship between the polymorphism of the XRCC1 Arg194Trp and CRC in Chinese population were searched in both English and Chinese databases. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. All analyses were conducted in Stata 12.0. Results A total of 11 case-control studies with 2710 cases and 3567 controls on XRCC1 Arg194Trp were included the Meta-analysis, and significant increased risks were found in additive models [(T vs C): OR (95%CI)=1.18 (1.01-1.39), P=0.036], homozygote comparison [(TT vs CC): OR (95%CI) =1.39 (1.02-1.90), P=0.038], Dominant models [(CT/TT vs CC): OR (95%CI) =2.24 (1.78-2.82), P<0.001], and recessive models [(TT vs CT/CC): OR (95%CI)=1.23 (1.02-1.49), P=0.030]. No publication bias was found in all genetic model. Conclusion In Chinese population, individuals carrying mutation allele T or homozygous mutation TT may have an increased risk of developing CRC, furthermore, individuals with the CT/TT genotype significantly increased the risk of suffering from CRC.关键词
DNA损伤修复基因/XRCC1/结直肠癌/遗传多态性/肿瘤易感性Key words
XRCC1/Colorectal cancer/Genetic polymorphism/Cancer susceptibility分类
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黄盛鑫,周军,李英儒,彭启全,谢锷,王小忠..DNA损伤修复基因XRCC1 Arg194Trp 基因多态性与中国人群结直肠癌易感性的Meta分析[J].岭南现代临床外科,2016,16(4):396-401,6.
