护理学报2016，Vol.23Issue(14)：1-8,8.DOI:10.16460/j.issn1008-9969.2016.14.001
弥可保穴位注射治疗糖尿病周围神经病变的系统评价
Effect of Mecobalamin Point Injection Therapy on Diabetic Peripheral Neuropathy:A Systematic Review
摘要
Abstract
Objective To systematically evaluate the effect of mecobalamin point injection therapy on diabetic peripheral neuropathy (DPN) and its safety. Methods We electronically searched databases including The Cochrane Library, Medline, Embase, AMED, CINAHL, CMB, CNKI, VIP and Wanfang databases to collect randomized controlled trials on the effect of mecobalamin point injection therapy on DPN from the establishment of databases to December 2015. Two reviewers screened literature independently, extracted data and assessed the quality of included studies. Then meta-analysis was performed using RevMan 5.3 software or descriptive analysis. Results A total of 19 RCTs involving 1,571 patients were included. The results of meta-analysis indicated that: (1) The clinical total effective rate: the mecobalamin point injection group was higher than that of muscle injection group [OR=4.49, 95%CI(3.34, 6.04), P<0.00001] and intravenous injection group [OR=5.06, 95%CI(1.84, 13.87), P=0.002]. (2)Motor nerve conduction velocity: the median and common peroneal nerve MNCV improvement of mecobalamin point injection group was better than that of muscle injection group [MD=5.58, 95%CI(4.77, 6.39), P<0.00001];[MD=4.66, 95%CI(2.89, 6.43), P<0.00001]. (3) Sensory nerve conduction velocity: the median, common peroneal and superficial peroneal nerve SNCV improvement of mecobalamin point injection group were better than those of muscle injection group [MD=4.12, 95%CI(2.94, 5.30), P<0.00001]; [MD=4.21, 95%CI(3.29, 5.14), P<0.00001]; [MD=3.28, 95%CI(1.95, 4.61), P<0.00001]. (4)Safety: three studies revealed symptoms of local pain and soreness, but restored after processing or resting and no other adverse reactions were reported. Conclusion The clinical effect of mecobalamin point injection is better than that of muscle injection, intravenous injection, intravenous drip and oral. But compared with intravenous injection, the median nerve MNCV improvement of mecobalamin point injection has no obvious advantage. Because of the quality and quantity of the literatures, the conclusion of the study needs to be confirmed through more high-quality randomized controlled trials.关键词
弥可保/穴位注射/糖尿病周围神经病变/系统评价/Meta分析Key words
mecobalamin/point injection/diabetic peripheral neuropathy/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
朱蓉,高静,吴晨曦,柏丁兮,李迎春,叶艳,吴霜..弥可保穴位注射治疗糖尿病周围神经病变的系统评价[J].护理学报,2016,23(14):1-8,8.基金项目
四川省科技厅科技支撑计划项目 （）
