中南医学科学杂志2016，Vol.44Issue(3)：241-246,250,7.DOI:10.15972/j.cnki.43-1509/r.2016.03.001
CXC类趋化因子受体4基因多态性对新辅助化疗宫颈癌患者疗效及预后的影响
CXCR-4 gene Polymorphism and the Response in Cervical Cancer Patients Treated with Neoadjuvant Chemotherapy Major
温展翀 1陈勍 2黄妙玲 2巴音吉力 2徐干如 1田春芳1
作者信息
- 1. 深圳市第七人民医院妇产科，广东 深圳518081
- 2. 中山大学孙逸仙纪念医院妇科肿瘤
- 折叠
摘要
Abstract
Objective To explore the influence of CXCR-4 gene polymorphism on the chemotherapeutic response and prognosis of cervical cancer patients who received NACT followed radical surgery. Methods 62 patients were en-rolled in this study;Samples were recruited from the formalin-fixed,paraffin-embedded surgical specimens.DNA was extrac-ted using the QIAamp DNA FFPE Tissue Kit;PCR of paraffin block genomic DNA;Direct sequence of DNA:All PCR prod-ucts were further purified for commercial sequencing. Results The length of the amplicon is 236bp; The CXCR4 geno-type distributions were 25 CC (40.3%),37CT (59.7%) and 0 TT (0.0%);Most clinicopathologic results failed to show a significant relationship with polymorphism except tumor grade.;The association CXCR4 gene polymorphism and response to chemotherapy:A statistically significant association was not found and favorable treatment with platinum based chemothera-py;The influence of CXCR4 gene polymorphism on survival:CXCR4 polymorphisms were not related to DFS or OS ( P>0. 05) . Conclusion There are associations with CXCR4 polymorphisms and the prognosis of cervical cancer patients;. CXCR4 polymorphism has no significant association with the chemotherapeutic response of cervical cancer patients who re-ceived with platinum based neoadjuvant chemotherapy.关键词
趋化因子受体4/新辅助化疗/宫颈癌/生存预后/化疗反应Key words
CXCR-4 gene/Neoadjuvant chemotherapy/Cervical cancer/Prognosis/Response to chemotherapy分类
医药卫生引用本文复制引用
温展翀,陈勍,黄妙玲,巴音吉力,徐干如,田春芳..CXC类趋化因子受体4基因多态性对新辅助化疗宫颈癌患者疗效及预后的影响[J].中南医学科学杂志,2016,44(3):241-246,250,7.
