中南医学科学杂志2016，Vol.44Issue(3)：247-250,4.DOI:10.15972/j.cnki.43-1509/r.2016.03.002
不同类型P TX治疗复发性卵巢癌的临床效果分析
Analysis of Clinical Effect of Different Types of PTX for the Treatment of Recurrent Ovarian Cancer
何海燕1
作者信息
- 1. 无锡市第三人民医院妇产科，江苏 无锡214000
- 折叠
摘要
Abstract
Objective To study the clinical effects and side effects of albumin combined with paclitaxel ( PTX) and PTX liposome combined with nedaplatin chemotherapy for the treatment of recurrent ovarian cancer. Methods 97 patients with advanced recurrent ovarian cancertreated by oncology chemotherapy were retrospectively analyzed, 51 patients were treated with albumin binding PTX+nedaplatin therapy ( albumin group) , 46 patients were treated with PTX liposome+ Nida platinum therapy ( liposome group) , the clinical effect, toxicity and prognostic differences of the two groups were compared. Results Remission rate of albumin group ( 52. 94%) was significantly higher than the liposome group (32. 61%)(P<0.05),and the efficiency is 73.91% and 84.31%,repectively(P>0.05).Serious adverse reaction rates showed no significant difference in the two groups (P>0.05);Survival rates of patients of 1 and 2-year(78.43%, 47.06 vs 67.39%% 30.43% )had no significant difference (P>0.05)in the albumin group and liposome group.But,the 3-year sur-vival of albumin group is higher than that of the liposome group (29.41% vs 13.04%) (P<0.05). Conclusion Treat-ment of recurrent ovarian cancer patients with albumin together PTX and nedaplatin is better than that of PTX liposomes and Nedaplatin but without increasing toxicity.关键词
白蛋白结合型紫杉醇/紫杉醇脂质体分/奈达铂/复发性卵巢癌Key words
albumin-bound paclitaxel/paclitaxel liposome points/nedaplatin/recurrent ovarian cancer分类
临床医学引用本文复制引用
何海燕..不同类型P TX治疗复发性卵巢癌的临床效果分析[J].中南医学科学杂志,2016,44(3):247-250,4.
