中南医学科学杂志2016，Vol.44Issue(3)：255-257,3.DOI:10.15972/j.cnki.43-1509/r.2016.03.004
妊娠期糖尿病产妇胎盘与血清脂联素水平的相关性
The Relationship Between the Placenta and Serum Adiponectin Level in Patients with Gestational Diabetes Mellitus
李华珍 1袁俏奇 1罗利 1黄薇 1许金华2
作者信息
- 1. 广州医科大学附属第四医院妇产科，广东 广州511447
- 2. 南华大学护理学院
- 折叠
摘要
Abstract
Objective To study the relationship of placenta adiponectin level with insulin resistance and serum adi-ponectin level in patients with gestational diabetes mellitus. Methods 30 patients in our hospital from October 2014 to September 2015 were selected as study group,and pregnant woman in childbirth at the same time were selected as control group.Immunohistochemistry was used to detect the expression level of APN in trophoblast cells.The relationship of placenta adiponectin level with insulin resistance,serum adiponectin level,prenatal body mass index,weight and length of newborn was analyzed. Results Positive reaction in placental trophoblast cells could be observed in the control group,and the ex-pression of the positive reaction in the study group was weaker than that in the control group.The expression amount of APN in control group and study group were ( 62. 54 ± 3. 36 ) and ( 37. 12 ± 2. 79 ) respectively ( t=8. 496, P=0. 000 ) . The trophoblast APN level was negatively correlated with BMI in placenta,prenatal HOMA-IR and neonatal birth weight. The trophoblast APN level was positively correlated with prenatal blood APN level (P<0.01).The trophoblast APN level was not correlated with neonatal birth length (P>0.05). Conclusion The trophoblast APN level was correlated with prenatal blood APN leve,insulin resistance and fetal growth and development,further studies on expression and mechanism of APN in placenta can provide a new way of thinking for the prevention and treatment of GDM.关键词
妊娠期糖尿病/脂联素/胎盘Key words
adiponectin/placenta/gestational diabetes mellitus分类
临床医学引用本文复制引用
李华珍,袁俏奇,罗利,黄薇,许金华..妊娠期糖尿病产妇胎盘与血清脂联素水平的相关性[J].中南医学科学杂志,2016,44(3):255-257,3.
