中南医学科学杂志2016，Vol.44Issue(3)：258-262,5.DOI:10.15972/j.cnki.43-1509/r.2016.03.005
肿瘤微环境中不同部位CD68＋巨噬细胞对鼻咽癌进展和预后的影响
Influence of CD68+Macrophages in Different Parts in the Tumor Microenvironment on Progression and Prognosis of Nasopharyngeal Carcinoma
摘要
Abstract
Objective This study was to investigate the influence of tumor-associated macrophages on the progression and prognosis of nasopharyngeal carcinoma (NPC). Methods 557 nasopharyngeal carcinoma paraffin specimens were col-lected in cancer center of Sun yat-sen university.Immunohistochemical staining method was used to detect macrophages molec-ular markers CD68, observe and count CD68 express numbers in nests and stroma, statistics are used to analyze the relationship between the positive cells from different parts with the clinical pathological characteristics and the prognosis of NPC patients. Results CD68+ macrophage infiltration in the stroma was more active than that in the nests (median:4.47 /HPF:1.87/HPF).Kaplan-Meier survival curve and the log-rank statistical analysis results show that the number of CD68+macrophages in nests had significant positive correlation with disease-free survival time and overall survival of NPC patients. The number of CD68+macrophages in interstitial also had significant positive correlation with disease-free survival time and o-verall survival of NPC patients.Single factor Cox proportional hazards model shows that the recurrent transfer (HR=0.667,P=0.667) and death ( HR=0. 626,P=0. 626) risk is lower with the more infiltration of CD68+ macrophage in the nests than a small number of patients after treatment. More number of CD68+ macrophages in the stroma has lower recurrence of transfer ( HR=0.664,P=0.664) and death risk ( HR=0. 66,P=0.66) of patients after treatment in patients than a small number. Conclusion The number of CD68+ macrophages infiltration in the nests and stroma of the immune microenvironment was positively related with the prognosis of NPC patients,and it reduced the risk of local recurrence and distant metastasis.关键词
肿瘤微环境/鼻咽癌/CD68/巨噬细胞Key words
tumor microenvironment/nasopharyngeal carcinoma/CD68/macrophages分类
医药卫生引用本文复制引用
蔡曼波,邵建永,曾益新,左建宏..肿瘤微环境中不同部位CD68＋巨噬细胞对鼻咽癌进展和预后的影响[J].中南医学科学杂志,2016,44(3):258-262,5.基金项目
国家高新技术研究和发展计划(863计划)(No:2012 AA02A501),国家基础研究发展计划(973计划)(No:2011 CB504805,2011 CB504300),国自基金(81272960)和省重点项目(2013WK2010) （863计划）
