中南医学科学杂志2016，Vol.44Issue(3)：275-278,282,5.DOI:10.15972/j.cnki.43-1509/r.2016.03.009
丁苯酞在大鼠脑缺血-再灌注损伤中的神经保护机制的研究
Butylphthalide in Mice Ischemia-reperfusion Injury of Nerve Protection Mechanism Research
廖梓亘 1陈慧2
作者信息
- 1. 南华大学附属第二医院神经内科，湖南 衡阳421001
- 2. 广州市中山大学孙逸仙纪念医院南院急诊科
- 折叠
摘要
Abstract
Objective To investigate the neuroprotection of Butylphthalide in mice after ischemia-reperfusion injury and its mechanism. Methods 56 clean-healthy SD rats were randomly divided into four groups:sham group,ischemic-reperfusion group,NBP for 24 hours group,NBP for 48 hours group.At the time of reperfusion after ischemia 2 h,the two NBP groups were treated with NBP (20 mg/kg,QD) by intraperitoneal injection until they were executed,also the sham group and the ischemic-reperfusion group were treated with the same dose of normal saline by intraperitoneal injection. Results The volume of cerebral ischemia in NBP-group was smaller than the ischemic-reperfusion group,what was more, the NBP-48 group was much more smaller than NBP-24 group,all had statistical significance(P<0.05).The number of BD-NF-positive cell in NBP-group was much more than the ischemic-reperfusion group,and NBP 48-group increased more obvi-ously than NBP-24 group,the difference was statistically significant (P<0.05). Conclusion Butyl phthalide injection can induce the expression of BDNF and have protective effect on rats nerve with ischemia-reperfusion injury.关键词
丁苯酞/SD大鼠/脑缺血/再灌注损伤/脑源性神经营养因Key words
Butylphthalide/SPrague-Dawley rats/brain ischemia/reperfusion injury/brain derived neuro-trophic factor分类
临床医学引用本文复制引用
廖梓亘,陈慧..丁苯酞在大鼠脑缺血-再灌注损伤中的神经保护机制的研究[J].中南医学科学杂志,2016,44(3):275-278,282,5.
