山东医药2016，Vol.56Issue(25)：13-16,4.DOI:10.3969/j.issn.1002-266X.2016.25.004
人结肠癌组织中 NIBP、CyclinE 和 CyclinD1蛋白表达变化及意义
Expression and cIinicaI significance of NIBP,CycIinE and CycIinD1 proteins in human coIon carcinoma
摘要
Abstract
Objective To observe the expression of NIK-IKK binding protein (NIBP),CyclinE and CyclinD1 in the tissues of patients with colon cancer,and to explore its clinical significance.Methods We collected 130 cases of samples from surgical resection and enteroscope biopsy of digestive internal medicine,65 cases of normal colon mucosa and 65 cases of cancer tissues in each group,all patients did not receive radiotherapy and chemotherapy.The expression of NIBP,Cy-clinE and CyclinD1 was detected by immunohistochemistry SP method,and then we analyzed the relationship between the positive expression of proteins and the clinicopathologic features in patients with colon cancer.The correlations between ex-pression of NIBP,CyclinE and CyclinD1 were determined by Pearson or Spearman tests.Results The positive expression rates of NIBP in the normal colonic mucosa and colon cancer tissues were 18.46% (12 /65)and 60.00% (39 /65),re-spectively;the positive expression rates of CyclinD1 were 3.08% (2 /65)and 56.92% (37 /65),respectively;and the positive expression rates of CyclinE were 43.08% (28 /65)and 89.23% (58 /65),respectively.Significant differences were found in the positive expression rates of NIBP,CyclinE and CyclinD1 between these two groups (all P <0.05).The expression of NIBP,CyclinE and CyclinD1 was significantly related with the depth of tumor invasion,TNMstaging,lymph node metastasis and distant metastasis in patients with colon cancer (all P <0.05).In the colon cancer tissues,the ex-pression of NIBP was positively correlated with CyclinE and CyclinD1 expression (r =0.43,0.32,all P <0.05),and the expression of CyclinD1 and CyclinE was positively correlated (r =0.23,P <0.05).Conclusion NIBP,CyclinE and Cy-clinD1 is highly expressed in the human colon cancer tissues,and they may participate in the occurrence and development of colon cancer tissues.关键词
结肠癌/NIK-IKK结合蛋白/周期蛋白E/周期蛋白D1Key words
colon carcinoma/NIK-IKK binding protein/CyclinE/CyclinD1分类
医药卫生引用本文复制引用
陈楚杰,黄杰安,徐春燕..人结肠癌组织中 NIBP、CyclinE 和 CyclinD1蛋白表达变化及意义[J].山东医药,2016,56(25):13-16,4.基金项目
广西自然科学基金资助项目（2013GXNSFAA019159）。 （）
