山西中医学院学报2016，Vol.17Issue(3)：17-19,22,4.
中医“同病异证”理论在老年期痴呆两个典型证候的Tau蛋白脯氨酸富集区磷酸化位点的体现
Reflect on Tau protein in proline-rich region of phosphorylation sites of two typical syndromes with senile dementia disease based on the same disease with different syndromes of Chinese medicine theory
摘要
Abstract
Objective:To observe Tau protein in proline-rich region of phosphorylation sites of two typical syndromes with senile dementia disease rat model and to analyze its specific phosphorylation of two syndromes,reflecting“the same disease with different syndromes”of Chinese medicine theory. Methods:Two carotid arteries were ligated one week apart,D-galactose was injected in intraperitoneal to establish Senile dementia rats model,subjected to fatigue of working and sexy stimuli and raise fat diet milk in the model on the basis of disease,then the corresponding rat model of senile dementia was established,which combined of disease and syndrome. Followed by Western blot method,to observed abnormal phosphorylation of Tau protein in the proline-rich region Thrl81,Thr205,Thr231,Ser262 phosphorylation sites. Result:In the Tau protein proline-rich region,compared with the Senile Dementia group,the disease with phlegm blocking orifices syndrome group significantly phosphorylation levels were increased at 205 and 231 sites,phosphorylation levels of the disease with kidney and essence deficiency syndrome group were significantly increased in 181,205,231 sites. Conclusion:All typical senile dementia syndromes have specific phosphorylation sites on Tau protein proline-rich region,revealing the scientific connotation of“the same disease with different syndrome”theory.关键词
老年期痴呆/证候/病证结合/Tau蛋白磷酸化位点Key words
senile dementia/syndrome/comlined disease with syndrome/phosphorylation sites of Tau protein分类
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郭斌,郭蕾,韩诚,师卫斌..中医“同病异证”理论在老年期痴呆两个典型证候的Tau蛋白脯氨酸富集区磷酸化位点的体现[J].山西中医学院学报,2016,17(3):17-19,22,4.基金项目
国家自然科学基金项目 （）
