山西中医学院学报2016，Vol.17Issue(4)：19-21,3.
川芎嗪对大鼠肾缺血再灌注损伤的保护作用及其机制
Effect of ligustrazine on acute renal ischemia reperfusion injury of rats and investigate its mechanisms of protective effect on renal injury
王娜 1许海江 2赵春玲2
作者信息
- 1. 杞县人民医院中药房，河南杞县475200
- 2. 郑州大学第一附属医院药剂科，河南郑州450002
- 折叠
摘要
Abstract
Objective:To observe the effect of ligustrazine on acute renal ischemia reperfusion injury of rats and investigate its mechanisms of protective effect on renal injury. Methods:50 SD rats were randomly divided into sham operation group, control group and ligustrazine group of low,medium and high dosage. Blood samples were taken before operation and 24 h after operation respectively,and contents of serum creatinine (SCr),urea nitrogen (BUN)were detected. All the rats were anaesthetized 24 h after operation again,and left kidney was removed,then the contents of SOD,MDA and TNF-α in tissue homogenate were detected and histological analysis was performed. Results:Compared with control group,contents of SCr,BUN,MDA and TNF-α and renal histology score were decreased and SOD activity was increased in ligustrazine groups of low,medium and high dosage with positive dose-dependent relationship. Conclusion:Ligustrazine has protective effect on acute renal ischemia reperfusion injury of rats through improving SOD activity of renal tissue and decreasing its contents of MDA and TNF-α.关键词
肾脏/再灌注损伤/川芎嗪/超氧化物歧化酶/丙二醛/肿瘤坏死因子Key words
kidney/reperfusion injury/igustrazine/SOD/MDA/TNF-α分类
医药卫生引用本文复制引用
王娜,许海江,赵春玲..川芎嗪对大鼠肾缺血再灌注损伤的保护作用及其机制[J].山西中医学院学报,2016,17(4):19-21,3.
