生物加工过程2016，Vol.14Issue(4)：59-64,6.DOI:10.3969/j.issn.1672-3678.2016.04.012
桂枝茯苓胶囊HPLC ESI QTOF／MS化学成分分析过程中提取溶剂的优化
Optimization of extraction solvent in the analysis of chemical composition in guizhi fuling capsules by HPLC-ESI-QTOF/MS
摘要
Abstract
The chemical components in Guizhi Fuling capsules by High Performance Liquid Chromatography⁃Electrospray Ionization⁃Quadruple Time of Flight⁃Mass Spectrometry( HPLC⁃ESI⁃QTOF/MS) with ESI source was reported. These compounds were analyzed with an Agilent Eclipse XDB⁃C18 (4. 6 mm×250 mm,5 μm)column by gradient elution using 0. 1% formic acid and acetonitrile.The data were acquired in positive ion and negative ion modes.Eighteen compounds in Guizhi Fuling capsules were identified rapidly by direct comparison in both positive and negative modes of QTOF/MS,the elemental compositions analysis,isotopic distribution,their fragmentation patterns and the previous references.It is a rapid and effective method which can be applied for the constituent identification of Guizhi Fuling capsules.关键词
HPLC ESI QTOF/MS/桂枝茯苓胶囊/化学成分/裂解途径Key words
HPLC-ESI-QTOF/MS/guizhi fuling capsule/chemical composition/fragmentation pathway分类
医药卫生引用本文复制引用
李维思,黄玲玲,李振江,唐美华,郭凯..桂枝茯苓胶囊HPLC ESI QTOF／MS化学成分分析过程中提取溶剂的优化[J].生物加工过程,2016,14(4):59-64,6.基金项目
国家自然科学基金青年基金 （）
