陕西师范大学学报（自然科学版）2016，Vol.44Issue(4)：70-76,7.DOI:10.15983/j.cnki.jsnu.2016.04.344
5-HT2C受体对帕金森病模型大鼠外侧缰核谷氨酸能神经元电活动的影响
Effects of 5-HT2C receptors on the firing activity of the glutamate neurons in the lateral habenular nucleus of the hemiparkinsonian rats
摘要
Abstract
To study the changes in firing activity of the glutamate neurons and the responses of the neurons to 5-hydroxytryptamine 2C (5-HT2C ) receptors stimulation in the lateral habenualr nucleus (LHb)in rats with unilateral 6-hydroxydopamine (6-OHDA)lesions of the substantia nigra pars compacta (SNc ), and clarify the role of the LHb and 5-HT2C receptors in the mechanism of PD,the firing activities of glutamate neurons in the LHb of sham-operated and the 6-OHDA-lesioned rats were assessed by electrophysiological study.The results showed that unilateral lesions of the SNc in rats led to a more bursting-firing activity of LHb glutamate neurons (P<0.05).Intra-LHb injection of Ro60-0175 as agonist of 5-HT2C receptors resulted in increase in the firing rate of LHb glutamate neurons (P<0.05)and the percentage of burst-firing neurons (P<0.05)in sham-operated and the 6-OHDA-lesioned rats.Compared to sham-operated rats,the duration of the excitatory effect produced by Ro60-0175 was markedly longer in the lesioned rats.These findings indicate that the changes in firing activity of glutamate neurons may be involved in the parkinsonian-related depression.And 5-HT2C receptors are involved in the regulation of the firing activity of glutamate neurons in the LHb.关键词
帕金森病/外侧缰核/谷氨酸能神经元/5-HT2C受体Key words
Parkinson′s disease/lateral habenular nucleus/glutamate neurons/5-HT2C receptors分类
基础医学引用本文复制引用
韩玲娜,王春雷,刘小静..5-HT2C受体对帕金森病模型大鼠外侧缰核谷氨酸能神经元电活动的影响[J].陕西师范大学学报（自然科学版）,2016,44(4):70-76,7.基金项目
陕西省自然科学基金 （）
