沈阳医学院学报2016，Vol.18Issue(4)：234-236,3.DOI:10.16753/j.cnki.1008-2344.2016.04.003
瘦素诱导乳腺癌三阴细胞系MDA-MB-231侵袭的形态学观察
Morphological Study for the Cell Invasiveness in Triple-negative Breast Cancer Cell Line MDA-MB-231 Induced by Leptin
摘要
Abstract
Objective:To study the influence of Leptin on cell invasiveness in triple-negative breast cancer cell line MDA-MB-231. Method:Cell scratching and Transwell invasion assay were used to observe the impact of Leptin on cell invasiveness. Results:Compared with the control group, Leptin could significantly enhance the MDA-MB-231 migration to the center of scratches. Transwell experiment found that, compared to control cells, the invasive ability of MDA-MB-231 cells significantly increased with Leptin induction. It was displayed for the increasing cells that had penetrated the basement membrane and spread well. Conclusion:Leptin can significantly induce the migration and invasiveness for the breast cancer MDA-MB-231 cells.关键词
瘦素/乳腺癌/MDA-MB-231/侵袭力Key words
Leptin/breast cancer/MDA-MB-231/invasiveness分类
基础医学引用本文复制引用
周伟强..瘦素诱导乳腺癌三阴细胞系MDA-MB-231侵袭的形态学观察[J].沈阳医学院学报,2016,18(4):234-236,3.基金项目
国家自然科学基金项目 （）
