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4种解释系统对HIV-1基因型耐药解释相关性评价OA

Evaluation of the Correlation of Four System for Testing HIV-1 Genotype Drug Resistance

中文摘要英文摘要

目的:比较HIVDB (7.0.1)、ANRS (25_09/2015)、REGA (9.1.0)和HIV GRADE (12/2015)4种解释系统对HIV-1基因型耐药结果解释的一致性。方法:选取我国3种主要HIV-1流行亚型和流行重组模式(B’、CRF01_AE和CRF07_BC),每种选取200条序列,共600条序列。分别用4种解释系统进行耐药结果分析,分为耐药(R)、中度耐药(I)和敏感(S)3个水平。对4种结果进行统计学分析。结果:4…查看全部>>

Objective:To compare the correlation of four drug-resistance interpretation system including HIVDB, ANRS, REGA and HIV GRADE for testing HIV-1 genotype drug resistance. Methods:Trendy subtypes and restructuring model of HIV-1 including B’,CRF01_AE and CRF07_BC were selected,each genotype was 200 series,600 samples were analyzed by four drug⁃resistance interpretation system, the results were divided into three levels including resistance (R), possible drug⁃re…查看全部>>

赫天一;关琪

沈阳医学院附属中心医院检验科,辽宁 沈阳 110024沈阳医学院附属中心医院检验科,辽宁 沈阳 110024

临床医学

HIV-1基因型耐药解释系统耐药突变

HIV-1genotype resistant interpretation systemdrug-resistant mutation

《沈阳医学院学报》 2016 (4)

237-241,5

辽宁省自然科学基金项目(No??2013020210);沈阳市科技计划项目(F16-206-9-15);沈阳医学院科技基金项目(No??20142049;20123044)

10.16753/j.cnki.1008-2344.2016.04.004

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