实用医学杂志2016，Vol.32Issue(11)：1777-1779,3.DOI:10.3969/j.issn.1006-5725.2016.11.015
非瓣膜病心房颤动患者VKORC1及CYP2C9基因多态性与华法林临床应用的关系
Relationship of VKORC1 and CYP2C9 gene polymorphism and warfarin in patients with non-valvular atrial fibrillation
摘要
Abstract
Objective To evaluate the guidance value of VKORC1 and CYP2C9 gene polymorphism on clinical application of warfarin in patients with non-valvular atrial fibrillation (NVAF). Methods A total of 290 cases of patients with NVAF were identified and their baseline data , initial dose of warfarin and base INR measurement results were recorded, then the follow-up was conducted. The initial administration of warfarin to INR standard time for the first time, total amount of warfarin and the average daily amount were recorded. All participants′ venous blood was extracted for VKORC1 and CYP2C9 gene polymorphism test. Results VKORC1 AG/GG genotype patients had longer INR standard time and higer amount of warfarin than patients with AA (103.38 ± 65.29)g vs. (53.26 ± 24.02)g, P < 0.05. Patients with type CYP2C9 gene mutation had shortest INR standard time(9.10 ± 2.01)d vs. (13.07 ± 4.28)d, P < 0.05. and lowest administration amount of warfarin (28.80 ± 17.35)g vs. (55.45 ± 23.67)g, P < 0.05. Conclusion There exist significant differences of first adminstration amount of warfarin in patients with NVAF to INR standards. Warfarin dose for VKORC1 AA genotype patients is lower than that for GG/AG type; there is short INR standard time and less adminstration amount of warfarin for CYP2C9 genotypes AC/CC patients.关键词
房颤/基因/华法林Key words
Atrial fibrillation/Gene/Warfarin引用本文复制引用
赵红丽,李潞,张晓丹,周佳萌,王晓昕,王小溪..非瓣膜病心房颤动患者VKORC1及CYP2C9基因多态性与华法林临床应用的关系[J].实用医学杂志,2016,32(11):1777-1779,3.基金项目
沈阳市科技创新专项资金（编号F14－182－1－00）；沈阳医学院科技基金项目 （）
