实用医学杂志2016，Vol.32Issue(11)：1806-1809,4.DOI:10.3969/j.issn.1006-5725.2016.11.024
TERT和CLK3基因多态性与膀胱癌的易感性
Association between genetic polymorphism of TERT and CLK3 with susceptibility of bladder cancer
摘要
Abstract
Objective To investigate the associations between the single nucleotide polymorphisms of TERT rs2736098, CLK3 rs11543198 and bladder cancer. Methods 201 bladder cancer cases and 200 healthy controls were included in the research, and the genotypes of TERT rs2736098 and CLK3 rs11543198 were determined using the PCR-RFLP method. Relationship between genotypes and bladder cancer risks was investigated. Results There were statistical significance in the rs2736098 genotype frequencies and allele frequencies between cases and controls (χ2= 6.973, P = 0.031; χ2= 7.412, P = 0.006). Compared with the individuals with the GG genotype , the risk of bladder cancer increased 2.069 times with the AA genotype (OR = 2.069, 95%CI: 1.181-3.624, P = 0.011). And there were no significant associations between the rs11543198 genotype frequencies and allele frequencies between cases and controls (χ2 = 0.202, P = 0.904; χ2 = 0.188, P = 0.665). Rs2736098 and rs11543198 genotype distribution in bladder cancer pathologic grade and stage had no statistical significance (P > 0.05). Conclusion Rs2736098 polymorphism is associated with risk of bladder cancer and rs11543198 polymorphism was not associated with risk of bladder cancer.关键词
膀胱肿瘤/TERT基因/CLK3基因/多态性Key words
Bladder cancer/TERT gene/CLK3 gene/Polymorphism引用本文复制引用
卢保德,刘德云,玉镇源,付伟金,程继文,陆浩源..TERT和CLK3基因多态性与膀胱癌的易感性[J].实用医学杂志,2016,32(11):1806-1809,4.基金项目
广西教育厅科研资助项目 （）
