实用医学杂志2016，Vol.32Issue(12)：1907-1911,5.DOI:10.3969/j.issn.1006-5725.2016.12.005
CUEDC2对梗阻性肾病小鼠肾组织炎症反应及间质纤维化的作用
Effects of CUEDC2 on inflammation and renal interstitial fibrosis in obstructive nephropathy
摘要
Abstract
Objective To study the effects of CUEDC2 on renal interstitial fibrosis and inflammation response in rats with unilateral ureteral obstruction (UUO). Methods 30 Balb/c rats were randomly distributed into sham operation group(sham-vector),uuo operation group(uuo-vector) and CUEDC2 treatment group after uuo (uuo-cuedc2). Hematoxylin-eosin and Masson staining were used to measure renal pathology; Inflammation factors were quantified by ELISA; Immunohistochemistry was performed to measure the expression of CUEDC2;Protein expression of CUEDC2, Fibronectin, E-cadherin, Collagen I were detected by Western Blot. Results At 7 and 14d after operation, the area of interstitial fibrosis and expression of ICAM1,MCP1,IL1,IL8, Fibronectin and Collagen I in uuo-cuedc2 showed a marked decrease when compared to uuo-vector (p?0.05),the level of E-cadherin was significantly increased (P < 0.05). Conclusion CUEDC2 can inhibit renal interstitial fibrosis and decrease the expression of inflammation factors and Collagen deposition.关键词
CUEDC2/Collagen I/炎症因子肾间质纤维化Key words
CUEDC2/Collagen I/Inflammation factors/Renal interstitial fibrosis引用本文复制引用
申萌,罗正茂,张虹,黄远航,李浪,何凤,童俊容..CUEDC2对梗阻性肾病小鼠肾组织炎症反应及间质纤维化的作用[J].实用医学杂志,2016,32(12):1907-1911,5.基金项目
国家自然科学基金 （）
