实用医学杂志2016，Vol.32Issue(12)：1962-1965,4.DOI:10.3969/j.issn.1006-5725.2016.12.020
乳腺癌腋窝淋巴结状态与分子病理特征的关系及临床意义
Relation of axillary lymph node status and molecular indexes in breast cancer and its significance
摘要
Abstract
Objective To investigate the relationship between axillary lymph node status and molecular pathological features in breast cancer and its clinical significance. Methods A retrospective analysis was performed to study the relationship of axillary lymph node metastasis (LNM), positive lymph node (PLN), and lymph node ratio (LNR) with clinical and molecular pathology features in 300 patients with breast cancer. Results Of 300 cases of breast cancer, the positive rate of axillary LNM was 31.0% (13/42) in the Luminal A subtype of breast cancer, yielding a statistically significant difference (P < 0.05), compared with that of other molecular subtypes. Of 144 patients with positive axillary LNM , there were no significant difference of LNR and PLN between different molecular subtypes of breast cancer (P > 0.05). PLN and LNR were all negatively correlated with E-cadherin expression in breast cancer (P < 0.01 and P < 0.05, respectively), correlated with tumor size and TNM staging (P < 0.05), but not with age, menopausal status, and histological grade (P > 0.05). Conclusion The combined phenotype expression of ER, PR, HER-2, and Ki67 (molecular subtypes) are associated with the incidence of axillary lymph node metastases , and E-cadherin expression deficiency and tumor size growth promote the progression of lymph node metastases in breast cancer.关键词
乳腺肿瘤/淋巴结转移/分子分型/分子特征Key words
Breast cancer/Lymph node metastasis/Molecular subtypes/Molecular features引用本文复制引用
邓淼,刘江波,张婷,刘德纯,邢鲁奇,陈登庭..乳腺癌腋窝淋巴结状态与分子病理特征的关系及临床意义[J].实用医学杂志,2016,32(12):1962-1965,4.基金项目
2015年度河南省医学科技攻关计划项目 （）
