天津中医药2016，Vol.33Issue(7)：385-389,5.DOI:10.11656/j.issn.1672-1519.2016.07.01
龙胆苦苷和龙胆碱的生物转化和药理活性研究进展
Progress in biotransformation and pharmacological activities of gentiopicroside and gentianine
摘要
Abstract
Gentiopicroside is one of important iri doid compounds, and the main active constituents of plants of the genus Gentiana, and can promote the gastric emptying and intestinal peristalsis and protecting liver, analgesic, anti-inflammatory and action. Gentianine has anti-inflammatory, antipyretic, sedative hypnotic, and anticonvulsant effect. Researchers have found that gentiopicroside and other iridoid compounds can be converted to gentianine and novel active components under the action of plant endophytic fungi and human intestinal bacteria. The gentiopicroside and gentianine in recent years in the pharmacological activity, biotransformation and metabolism is summarized in the article, to provide a theoretical basis for the further development and utilization of iridoid compounds and their metabolites.关键词
龙胆苦苷/龙胆碱/生物转化/药理活性Key words
gentiopicroside/gentianine/biotransformation/pharmacological activity分类
医药卫生引用本文复制引用
匡海学,吴高松,刘华,吴琼,王秋红,王知斌..龙胆苦苷和龙胆碱的生物转化和药理活性研究进展[J].天津中医药,2016,33(7):385-389,5.基金项目
国家重点基础研究发展计划-973计划（2013CB531801）；教育部博士点基金项目（20132327120002）；黑龙江中医药大学“优秀创新人才”支持项目（2012RCD05）；黑龙江中医药大学“杰出人才培养”基金项目（2012cj02）。 （）
