天津中医药2016，Vol.33Issue(7)：414-418,5.DOI:10.11656/j.issn.1672-1519.2016.07.09
菩人丹对T2DM胰腺微血管损伤大鼠胰岛β细胞功能及胰岛素抵抗的影响
Effect of Purendan on the pancreaticβcell secretion and IR in pancreas micro-circulatory damage in rats with T2DM
摘要
Abstract
Objective] To investigate the effect of Purendan (PRD) supermicro powder on the pancreaticβcell secretion in pancreas micro-circulatory damage in rats with T2DM, and explore the regulation mechanism for PRD in pancreaticβcell secretion. [Methods] Male wistar rats were administered intragastrically with fat milk and STZ and injected intravenously via the lateral caudal vein at a dose of 30 mg/kg. After 1 week, rats were randomly assigned to model group, PRD group, rosiglitazone maleate tablets group, and Jiangtang Tongmai tablet group. The 28 male wistar rats as control were also engaged in the experiment. Treatment were exerted according to grouping principles, and rats in control group and model group were administered intragastrically with the same dose of distilled water for 4 weeks. Then, oral glucose tolerance test, intravenous injection glucose-insulin release test, FINS-AUC/FBG-AUC, pancreatic β cell functional assessment and index of correlation were analyzed. [Results] In oral glucose tolerance test experiment, blood glucose in PRD group rats decreased within 2 h and was close to normal control, PG2 h approximated to plasma glucose level before given oral glucose [PG0 h:(14.80±1.42);PG2 h:(16.17±2.91) mmol/L]. In intravenous injection glucose-insulin release test, the significant secretion peak at the first phase were observed after 5 min in PRD treatment group, beside, secretion peak at the second phase were observed after 30 min, which conform to rapid and long pulsatile insulin secretion fashion. PRD significantly increased FINS-AUC/FBG-AUC (P﹤0.01). Meanwhile pancreaticβcell secretion were up-regulated, insulin secretion and sensitivity increased, and insulin resistivity decreased in PRD treatment group. [Conclusion] PRD supermicro powder possibly imporved glucose tolerance and insulin secretion in both phase via recovery of pancreaticβcell damage.关键词
菩人丹超微粉/2型糖尿病/胰腺微血管/胰岛β细胞/胰岛素抵抗Key words
Purendan supermicro powder/T2DM/pancreas micro-circulatory/pancreaticβcell/insulin resistance分类
医药卫生引用本文复制引用
刘祖涵,张梓倩..菩人丹对T2DM胰腺微血管损伤大鼠胰岛β细胞功能及胰岛素抵抗的影响[J].天津中医药,2016,33(7):414-418,5.基金项目
国家自然科学基金项目（30873249）。 （）
