现代妇产科进展2016，Vol.25Issue(7)：19-22,4.DOI:10.13283/j.cnki.xdfckjz.2016.07.005
PED/PEA-15及其磷酸化状态在卵巢上皮肿瘤中的表达及意义
The expression and significance of PED/PEA-15 and it's phosphorylation state in epithe-lial ovarian tumors
摘要
Abstract
Objective:To investigate the expression and clinical significance of PED/PEA-15 protein and its phosphorylation state in epithelial ovarian tumors. Methods:The posi-tive expression level of PED/PEA-15 and it's phosphorylation state in 40 cases of epithelial be-nign ovarian tumor,40 cases of epithelial ovarian borderline tumors and 50 cases of epithelial o-varian cancer was analyzed by immunohistochemical method. Results:The expression of PEA-15 protein in the benign group was higher than that in the borderline group and the malignant group (P<0. 05),and it's expression level was negative correlation with malignant degree and clinical stage of ovarian cancer(P<0. 05),but there was no significant correlation with the age of the patients. The expression level of PEA-15 phosphorylated at Ser104 protein was highly ex-pressed in ovarian cancer group and was also significantly associated with the histological grade and clinical stage of ovarian cancer(P<0. 05),but it had no obvious correlation with the age of the patients and lymph node metastasis in epithelial ovarian cancer ( P>0 . 05 ) . There were no significant differences in the expression of pPEA-15-Ser116 in different ovarian tissues,in differ-ent age,histological grade,clinical stage and lymph node metastasis (P>0. 05). Conclusion:PEA-15 and it's phosphorylation state play an important role in the occurrence and development of ovarian cancer. Whether the regulation of phosphorylation status of PED/PEA-15 can be used as an effective therapeutic marker in ovarian epithelial malignant tumor is still need to be fur-ther studied.关键词
卵巢上皮肿瘤/PED/PEA-15/pPEA-15-Ser104/pPEA-15-Ser116/免疫组化Key words
Ovarian epithelial tumor/PEA-15/pPEA-15-Ser104/pPEA-15-Ser116/Im-munohistochemistry分类
医药卫生引用本文复制引用
刘记,金兰,罗永红..PED/PEA-15及其磷酸化状态在卵巢上皮肿瘤中的表达及意义[J].现代妇产科进展,2016,25(7):19-22,4.基金项目
2014年皖南医学院重点科研项目培育基金(No:WK2014ZF11)“PED/PEA-15的表达及磷酸化状态在卵巢上皮癌中的作用研究” （No:WK2014ZF11）
