现代妇产科进展2016，Vol.25Issue(7)：511-514,4.DOI:10.13283/j.cnki.xdfckjz.2016.07.008
雌激素受体、酪氨酸激酶受体B在子宫腺肌病中的表达及意义
Expression and significance of ERs、TrkB in adenomyosis
雍敏婕 1李文倩 2刘波 3于晓辉2
作者信息
- 1. 银川市妇幼保健院妇产科，银川 753400
- 2. 大连市妇幼保健院暨大连医科大学附属妇产医院妇科，大连116033
- 3. 大连理工大学生物医学工程系，大连 116024
- 折叠
摘要
Abstract
Objective:To explore the role of estrogen receptors (ERs) and tyrosine kinase receptor B ( TrkB) in the pathogenesis of adenomyosis by detecting their expressions difference in eutopic or ectopic endometrial tissue. Methods:36 samples of eutopic endometrium and lesion tis-sues from patients with adenomyosis were collected (10 secretory and 26 proliferative phase) as the study group,and 21 patients with intraepithelial neoplasia grade (CIN) III (9 secretory and 12 pro-liferative phase) were as control group. The expressions of ERs and TrkB were detected by immuno-histochemistry SP method,and their intensity was analyzed by Imge-Pro-Plus 6 software. Results:The expressions of ER-β,TrkB and ER-β/ER-αin eutopic and ectopic endometrium of adenomyosis were significantly higher than that in control group (P<0. 05). The expressions of ER-β,TrkB and ER-β/ER-αin ectopic endometrium were significantly higher than that in eutopic endometrium ( P<0. 05). The expression of TrkB was positively correlated with that of ER-βin ectopic endometrium (P<0. 05). Conclusion:ER-βand TrkB may play important roles in the pathogenesis of adenomyo-sis.关键词
雌激素受体/酪氨酸激酶受体B/子宫腺肌病/子宫内膜Key words
Estrogen receptor/TrkB/Adenomyosis/Endometrium分类
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雍敏婕,李文倩,刘波,于晓辉..雌激素受体、酪氨酸激酶受体B在子宫腺肌病中的表达及意义[J].现代妇产科进展,2016,25(7):511-514,4.
