摘要
Abstract
Objective:To observe the transthyretin ( TTR) changes of maternal serum, and explore the role of TTR for diagnosis and serveillance in preeclampsia. Methods:In this nested case-control study, we collected pregnancy maternal serum samples to detect the TTR concentration. (1)We collected 62 normal childbearing age women serum samples to detect the TTR concentration changes at progestation, gravida at 12 ~16 weeks,20 ~24 weeks,28 ~32 weeks and 37~41 weeks of gestation. (2)Totally 30 patients with severe preeclampsia (SPE), 49 patients with gestational hypertension disorders ( GHD) and 50 pregnant woman with normal pregnancy outcomes and free pregnancy complication ( control group ) were included in this study. Serum was collected at the time of diagnosis of SPE or GHD,in the control group,serum was collected when the SPE group and the GHD group were collected respectively. Determina-tion of matemal serum TTR concentration using ELISA. Results:Normal progestation women se-rum TTR concentration was (245. 65±5. 02)mg/L. The TTR concentration in gravida at 12~16 weeks,20~24 weeks,28~32 weeks and 37~41 weeks of gestation with normal pregnancy respectively were (649. 86±43. 40)mg/L,(856. 10±52. 28)mg/L,(410. 04±22. 82)mg/L, (413. 71±24. 17) mg/L. Progestation women serum TTR concentration was the lowest. Serum TTR concentration were elevated at pregnancy duration,and up to peak at 20~24 weeks of ges-tation. Lower TTR levels were observed following the 20~24 weeks of gestation. SPE pregnancy serum TTR concentration was (86. 58±10. 23)mg/L. GHD pregnancy serum TTR concentration was (468. 59±42. 93)mg/L. Control group maternal serum TTR concentration was (411. 64± 25. 80)mg/L. There was difference of TTR concentration between SPE group and control group ( P<0 . 01 ) . There was difference of TTR concentration between SPE group and GHD group ( P<0 . 05 ) . There was no difference of TTR concentration between GHD group and control group (P>0. 05). Conclusion:Serum TTR concentration were elevated at pregnancy duration,and upto peak at 20~24 weeks of gestation. Then lower TTR levels were observed following the 20~24 weeks of gestation. TTR level is critical for early prediction, prognosis, monitoring and treatment responses of PE.关键词
子痫前期/转甲状腺素蛋白/诊断Key words
Preeclampsia/Transthyretin/Diagnosis分类
医药卫生
