中国组织工程研究2016，Vol.20Issue(28)：4176-4181,6.DOI:10.3969/j.issn.2095-4344.2016.28.011
骨髓间充质干细胞移植对糖尿病模型大鼠肾脏的保护作用
Stem cell transplantation protects the kidney in diabetic rat models
甘利明1
作者信息
- 1. 武汉市中心医院内分泌科，湖北省武汉市 430014
- 折叠
摘要
Abstract
BACKGROUND:So far numerous theoretical studies have shown the treatment effect of stem cel transplantation for chronic complications of diabetes, while its treatment effects on diabetic nephropathy have not yet been confirmed in animal models. OBJECTIVE:To investigate the protective effect of bone marrow mesenchymal stem cel transplantation on the kidney in rat models of diabetes. METHODS:Rats were fed with high-sugar and high-fat diet for 4 weeks, and then were given injection of streptozotocin to establish type 2 diabetic rat models. At 2 days after modeling, bone marrow mesenchymal stem cel s were injected via the tail vein (stem cel transplantation group). In the meanwhile, control and diabetes groups were established. At 21 days after cel transplantation, levels of glucose, triglyceride and insulin in the tail vein were detected. Additional y, morphological observations of kidney and pancreatic tissues were performed. RESULTS AND CONCLUSION:The levels of blood sugar, insulin and triglycerides in the diabetes group were significantly higher than those of the control group (P<0.05). Blood glucose and insulin levels in the stem cel transplantation group were significantly lower than those of the diabetes group (P<0.05). In addition, mesangial area and glomerular volume in the stem cel transplantation group were significantly lower compared with the diabetes group (P<0.05). These results confirm that bone marrow mesenchymal stem cel transplantation can reduce levels of blood glucose and serum insulin, contributing to the repair of damaged pancreas and kidney.关键词
干细胞/移植/骨髓间充质干细胞/大鼠/糖尿病/肾脏/胰岛素/动物实验/胰腺/血糖/三酰甘油/胰岛素抵抗分类
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甘利明..骨髓间充质干细胞移植对糖尿病模型大鼠肾脏的保护作用[J].中国组织工程研究,2016,20(28):4176-4181,6.
