中国组织工程研究2016，Vol.20Issue(30)：4547-4553,7.DOI:10.3969/j.issn.2095-4344.2016.30.020
梯度复合羟基磷灰石/二氧化锆组织工程骨：应用现状及进展
Hydroxyapatite/zirconia gradient composite scaffolds for bone tissue engineering:current uses and perspectives
摘要
Abstract
BACKGROUND:Porous gradient hydroxyapatite/zirconia composite, which can adhere to a variety of cel s, such as osteoblasts, bone marrow mesenchymal stem cel s and chondrocytes, can induce and promote fracture healing or replace bone defects. OBJECTIVE:To review the development and application of porous gradient hydroxyapatite/zirconia composite in bone tissue engineering. METHODS:Articles related to porous gradient hydroxyapatite/zirconia composite in bone tissue engineering were retrieved in CNKI and PubMed databases (1971-01/2014-12). The key words were“porous bioceramic, bone tissue engineering, bone morphogenetic protein-2, induced pluripotent stem cel s”in Chinese and English, respectively. A total of 54 articles based on inclusion criteria and exclusion criteria were obtained for the review. RESULTS AND CONCLUSION:Porous gradient hydroxyapatite/zirconia composite can provide a scaffold to induce natural y forming bone growing to fil the three-dimensional pores, thus realizing the perfect integration of tissue-engineered bone material and host-bone tissue. As zirconia functions as an enhancer of hydroxyapatite, high-quality artificial bone materials, which have elastic modulus, fracture toughness and structure similar to human bone, can be prepared by adjusting the proportion and porosity of materials. Additional y, the new hydroxyapatite/zirconia foamed ceramics as tissue-engineered bone carrying bone morphogenetic protein-2/chitosan gel sustained release system and bone marrow mesenchymal stem cel s derived from induced pluripotent stem cel s wil be expected to increase bone formation and bone fusion rates significantly in the future.关键词
生物材料/骨生物材料/泡沫陶瓷/骨组织工程/骨形态发生蛋白/诱导性多能干细胞/组织构建分类
医药卫生引用本文复制引用
邵荣学,黄小龙,胡华辉,全仁夫,谢尚举,李希..梯度复合羟基磷灰石/二氧化锆组织工程骨：应用现状及进展[J].中国组织工程研究,2016,20(30):4547-4553,7.基金项目
浙江省科技厅计划项目(2012C33114) （2012C33114）
