厦门大学学报（自然科学版）2016，Vol.55Issue(4)：478-484,7.DOI:10.6043/j.issn.0438-0479.201511002
来源于链霉菌Streptomyces albiflaviniger 菌株YN-10-2的纳皮拉霉素类化合物的结构和活性
Structures and Bioactivities of Napyradiomycins Compounds from Streptomyces albiflaviniger YN-1 0-2
摘要
Abstract
A rhizosphere strain Streptomyces albiflaviniger YN-10-2 isolated from Cycas panzhihuaensis Zhou L et Yang S Y at Yunnan University was chosen to study its secondary metabolites.Six napyradiomycins compounds were purified from 20 L solid fer-mentation culture.Their chemical structures were elucidated mainly by spectroscopic analyses including nuclear magnetic resonance (NMR)spectroscopy and electrospray ionization mass spectroscopy(ESI-MS).Results showed that these six compounds were identi-fied as napyradiomycin B1(1),napyradiomycin B3(2),napyradiomycin C1(3),napyradiomycin A2a(4),napyradiomycin A2b(5)and 3-chloro-6,8-dihydroxy-8-α-lapachone(6),respectively.Among these compounds,napyradiomycins A2a(4)and A2b(5)are epimers. Additionally,compounds 1-3 exhibited inhibitory activities against Staphylococcus aureus in the antimicrobial tests by disc diffusion assay.关键词
根际链霉菌/纳皮拉霉素/核磁共振/差向异构体/抗菌活性Key words
rhizosphere Streptomyces/napyradiomycin/nuclear magnetic resonance(NMR)/epimer/antimicrobial activity分类
医药卫生引用本文复制引用
郭凯,胡志钰,郑忠辉,徐庆妍..来源于链霉菌Streptomyces albiflaviniger 菌株YN-10-2的纳皮拉霉素类化合物的结构和活性[J].厦门大学学报（自然科学版）,2016,55(4):478-484,7.基金项目
厦门市科技计划项目(3502z20123010) （3502z20123010）
