厦门大学学报（自然科学版）2016，Vol.55Issue(4)：506-509,4.DOI:10.6043/j.issn.0438-0479.201508019
叶片山海绵水溶性活性产物的大孔吸附树脂分离及其抗肿瘤活性
The Enrichment Product from Sponge Mycale phyllophila Water Extract by a Macroporous Resin and Its Anti-tumor Activity
摘要
Abstract
Marine sponges contain abundant bioactive compounds.This study established a method that a DA201-C macroporous ad-sorption resin was used to enrich bioactive products from Mycale phyllophila water extract.Lowry's assay showed that this method recovered about 57% of the total small molecular peptides from the water extract.The majority compounds of the enrichment product are peptides,accounting for about 89%.In addition,the enriched product has obvious inhibitory activities to C6 glioma cells, A2780-CP ovarian cancer cisplatin-resistant cells and HepG2 hepatoma cells.This study lays the foundation for in-depth study on the anti-tumor compound from M.phyllophila water extract.关键词
海绵/大孔吸附树脂/肽类/抗肿瘤活性Key words
marine sponge/macroporous adsorption resin/peptide/anti-tumor activity分类
海洋科学引用本文复制引用
贺腾飞,罗联忠,陈军,王德祥,丁少雄..叶片山海绵水溶性活性产物的大孔吸附树脂分离及其抗肿瘤活性[J].厦门大学学报（自然科学版）,2016,55(4):506-509,4.基金项目
厦门南方海洋研究中心项目(13GYY002NF07) （13GYY002NF07）
