中国医疗设备2016，Vol.31Issue(7)：19-21,3.DOI:10.3969/j.issn.1674-1633.2016.07.006
能谱CT评价兔VX2肝癌抗血管生成治疗的实验研究
Experimental Study on the Evaluation of Anti-Angiogenesis Therapy in Rabbit VX2 Liver Cancers by Spectrum CT
摘要
Abstract
Objective To explore the effectiveness of application of the spectral CT for the treatment of endostatin of the rabbit VX2 liver cancer model. Methods The 68 rabbits with VX2 liver tumors were randomly and evenly divided into Control Group and Trial Group with 34 rabbits in either group. From the 14 d after tumor transplantation, Group A was injected with endostain at the dose of 0.3 mg/kg continuously for 7 d;while, Group B was injected with saline and endostain at the same dose of 0.3 mg/kg with Group A continuously for 7 d, The rabbits were scanned to obtain gemstone spectral images. The reconstructed image data were transmitted to the image processing workstation for analysis. The iodine content of the tumor, area without tumor and the abdominal aorta were measured in the iodine map to calculate NIC (Normalized Iodine Concentrations). And the pre-and post-treatment NIC was compared. Results The NIC of the tumor tissue in both Group A and Group B were higher than the liver tissue without tumor, with statistically significant difference (P<0.05). After the endostatin Endostar treatment, the NIC of tumor of Trail Group was less than that of Control Group, and less than pre-trestment NIC, with statistically significant (P<0.05). Conclusion The endostain Endosar showed obvious antiangiogenic effects in spectrum CT scan to evaluate the tumor angiogenesis and the effect of the anti-angiogenesis therapy.关键词
兔VX2肝癌模型/能谱CT/碘含量/血管内皮抑制素/肿瘤血管生成Key words
rabbit VX2 liver cancer model/spectral computed tomography/iodine content/endostatin/tumor angiogenesis分类
医药卫生引用本文复制引用
王明月,周悦,董军强,高剑波..能谱CT评价兔VX2肝癌抗血管生成治疗的实验研究[J].中国医疗设备,2016,31(7):19-21,3.基金项目
河南省医学科技攻关项目（201204008）。 （）
