医药导报2016，Vol.35Issue(8)：828-831,4.DOI:10.3870/j.issn.1004-0781.2016.08.006
不同透皮吸收促进剂对消炎润麻胶浆透皮吸收作用的影响∗
Effect of Different Penetration Enhancers on Percutaneous Absorption of Xiaoyan Runma Mucilage
摘要
Abstract
Objective To investigate the effects of different penetration enhancers on percutaneous absorption of Xiaoyan Runma mucilage in vitro, and to improve the curative efficacy of this mucilages through selection of the effective penetration enhancers. Methods Xiaoyan Runma mucilage was prepared with different penetration enhancers. An intelligent permeability instrument was used for in vitro percutaneous absorption test of rats , with isolated mice abdomen skin serving as in vitro transdermal barrier and saline isotonic solution as receptor fluid. Then the contents of lidocaine hydrochloride in receptors were determined by HPLC.The accumulative transit dose (Q) and percutaneous permeability (J) within 12 h were calculated and compared with those of mucilage without any enhancer. Results With Q value serving as an index, different enhancers had different promote permeation effects on Xiaoyan Runma mucilage, and the effects in descending order were as follows:4% azone [(222.75±3.4) μg•(cm2)-1]>2% azone[(207.42±5.1) μg•(cm2)-1]>3% menthol [(183.38±4.9) μg•(cm2)-1]>5%menthol [(160.82±5.4) μg•(cm2)-1]>2% azone+3% menthol [(151.25±5.5) μg•(cm2)-1]>2% azone+5% isopropyl myristate [(127.26±7.1) μg•(cm2)-1]>2% oleic acid [(125.16±6.5) μg•(cm2)-1]>no enhancer [(109.82±8.2)μg•(cm2)-1].4% azone was the best penetration enhancer for the mucilage delivery in vitro, with Q and J value as [(222.75± 3.4)μg•( cm2 )-1 ] and 19. 896 μg•( cm2 )-1•h-1 , respectively, which was 2. 08 times those of mucilages without any enhancer. Conclusion Being as a transdermal absorption enhancer of Xiaoyan Runma mucilage, 4% azone has the best effect. This study can provide the optimal formulation for transdermal delivery system of Xiaoyan Runma mucilage.关键词
消炎润麻胶浆/透皮促进剂/透皮吸收Key words
Xiaoyan Runma mucilage/Penetration enhancer/Percutaneous absorption分类
医药卫生引用本文复制引用
赵玉娜,高婷,陈晶..不同透皮吸收促进剂对消炎润麻胶浆透皮吸收作用的影响∗[J].医药导报,2016,35(8):828-831,4.基金项目
宁夏自然科学基金资助项目( NZ13141) （ NZ13141）
