中国康复理论与实践2016，Vol.22Issue(7)：765-768,4.DOI:10.3969/j.issn.1006-9771.2016.07.005
电针预处理对大鼠脑缺血再灌注损伤后炎性因子及细胞凋亡的影响
Effects of Electro-acupuncture Pretreatment on Interleukin-1β, Interleukin-6 and Apoptosis in Rats after Cere-bral Ischemia-reperfusion Injury
摘要
Abstract
Objective To investigate the effect of electro-acupuncture pretreatment on content of interleukin (IL)-1βand IL-6 in serum and ischemic penumbra, and apoptosis in ischemic penumbra in rats after cerebral ischemia-reperfusion injury. Methods Thirty-six male Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12), and electro-acupuncture pretreatment group (n=12). The middle cerebral arteries were occluded for 120 minutes and reperfused. Twenty-four hours after reperfusion, the level of IL-1βand IL-6 in serum and brain tissue was detected with enzyme-linked immunosorbent, and apoptosis of ischemic penumbra was detected with TU-NEL. Results The content of IL-1βand IL-6 in the serum and brain tissue, and the number of TUNEL-positive cells decreased in the elec-tro-acupuncture pretreatment group compared with that in the model group (P<0.01). Conclusion Electro-acupuncture pretreatment may in-hibit inflammatory response and apoptosis in cerebral ischemia-reperfusion injury.关键词
脑缺血再灌注/电针/预处理/白细胞介素-1β/白细胞介素-6/细胞凋亡/炎症反应/大鼠Key words
cerebral ischemia-reperfusion/electro-acupuncture/pretreatment/interleukin-1β/interleukin-6/inflammatory response/apoptosis/rats分类
医药卫生引用本文复制引用
朱路文,叶涛,姜云飞,吴孝军,李宏玉,宋名扬,唐强..电针预处理对大鼠脑缺血再灌注损伤后炎性因子及细胞凋亡的影响[J].中国康复理论与实践,2016,22(7):765-768,4.基金项目
1.哈尔滨市科技创新人才专项基金项目(青年后备人)(No.2014RFQGJ150)；2.黑龙江省自然科学基金项目(No.QC2015103)；3.国家自然科学基金项目(No.81503666)。 （青年后备人）
