中国临床药理学杂志2016，Vol.32Issue(13)：1155-1157,3.DOI:10.13699/j.cnki.1001-6821.2016.13.001
舍曲林联合泛昔洛韦治疗带状疱疹神经痛的临床研究
Clinical trial of seculin combined with famciclovir in the treatment of herpes zoster neuralgia
摘要
Abstract
Objective To investigate the clinical efficacy of sertraline combined with famciclovir in treatment of herpes zoster neuralgia . Methods Ninety -four patients with herpes zoster neuralgia were randomly divided into treatment group and control group , 47 cases in each group. Two groups of patients were performed conventional nutritional and physical therapy . Control group was treated with oral administration of famciclovir 0.25 g, tid, treatment group added sertraline 50 mg・ d-1 on the basis of control group . The course of treatment was 4 weeks. The visual analogues scale ( VAS ) , clinical efficacy , quality of life and the adverse drug reactions were compared between the two groups.Results In the treatment group , the VAS in 1 and 4 weeks were ( 5.13 ±1.26 ), (3.27 ±1.02), significantly decreased than before treatment ( P<0.05 ) , and significantly lower than control group, which were(6.17 ±1.57) and (4.87 ±1.13).The total effective rate in treatment group ( 93.62%) was higher than control group ( 74.47%, P <0.05 ) .The quality of life in two groups were significantly increased after treatment ( P<0.05 ) , and treatment group significantly higher control group (P<0.05).No serious adverse drug reaction was found in two groups.Conclusion The clinical efficacy of seculin combined with famciclovir in the treatment of herpes zoster neuralgia is significant.关键词
舍曲林/泛昔洛韦/带状疱疹神经痛Key words
seculin/famciclovir/herpes zoster neuralgia分类
药学引用本文复制引用
皮治兵,林海,彭宇,金元..舍曲林联合泛昔洛韦治疗带状疱疹神经痛的临床研究[J].中国临床药理学杂志,2016,32(13):1155-1157,3.基金项目
浙江省医药卫生平台骨干人才计划基金资助项目 （）
