中国临床药理学杂志2016，Vol.32Issue(13)：1162-1165,4.DOI:10.13699/j.cnki.1001-6821.2016.13.003
替罗非班对急性 ST段抬高型心肌梗死介入治疗的临床研究
Clinical trial of tirofiban on interventional therapy of acute ST segment elevation myocardial infarction
摘要
Abstract
Objective To explore the effect of tirofiban intracoronary in-jection on hemodynamics in patients with acute ST -segment elevation myocardial infarction ( STEMI ) after percutaneous coronary intervention ( PCI) .Methods Five hundred and six cases of patients with acute STEMI in our hospital from November 2011 to November 2012 were se-lected, who were divided into experiment group and control group accor-ding to the random digital table method , with 253 cases in each group. The control group were treated heparin 5000 U by intraoperative arterial sheath injection during PCI operation , after operation who were treated with low molecular weight heparin subcutaneous injection of 5000 U, for 5 d.The experiment group were given injection of tirofiban by the dose in 5 μg・ kg -1 ,completing within 3 min before PCI operation , and then the tirofiban for 36 h of continuous infusion , in 0.15 μg・ kg -1・ min -1 .The changes of blood flow , heart function indexes and reperfusion indexes were observed before and after treatment in two groups .Results There was no significant difference in TIMI blood flow between the two groups before treatment ( P >0.05 ) , which were significantlly improved compared with those before treatment ( P<0.05 ) , and the blood flow of the experiment group after treatment was obviously better than that of the control group (P<0.05).There were no significant differences in left ventricular ejection fraction (LVEF)[(43.1 ±3.25)%vs (42.69 ±3.22)%], left ventricular end diastolic diameter (LVEDD)[(41.05 ±3.22)mm vs (41.09 ±3.31) mm], left ventricular end systolic diameter (LVESD)[(31.66 ±4.65)mm vs (31.05 ±4.59)mm] levels between the two groups before treatment ( P>0.05 ) .The cardiac function indexes of the two groups were significantly improved after treatment than those before treatment .After treatment , the LEVF value of the experiment group was significantly higher than that of the control group [(58.14 ±6.85)%vs (46.12 ±4.15)%], and the LVEDD[(43.11 ±3.12)mm vs (49.79 ±4.52)mm] and LVESD[(34.01 ±5.17)mm vs (39.88 ±5.13)mm] levels were significantly lower than those in the control group (P<0.05).The arterial blood flow classification , 90 minST segment fall more than 50%, CK-MB peak and CK-MB peak time and other indicators in the experiment group were significantly better than those in the control group (P<0.05).Conclusion The application of tirofiban for coronary artery injection can effectively improve hemodynamics , heart function indexes in patients with STEMI in PCI .关键词
替罗非班/急性ST段抬高型心肌梗死/冠脉介入治疗/血流动力学Key words
tirofiban/acute ST segment elevation myocardial infarction/percutaneous coronary intervention/hemodynamics分类
医药卫生引用本文复制引用
杜蕊,张冬梅,李颖,王超,刘奇,刘长青..替罗非班对急性 ST段抬高型心肌梗死介入治疗的临床研究[J].中国临床药理学杂志,2016,32(13):1162-1165,4.基金项目
河北省医学科学研究课题基金资助项目 （）
