中国临床药理学杂志2016，Vol.32Issue(13)：1178-1181,4.DOI:10.13699/j.cnki.1001-6821.2016.13.008
阿立哌唑联合氯氮平对精神分裂症患者糖脂代谢与睡眠及体重的影响
Effect of aripiprazole combined with clozapine on glucolipid metabolism, sleep and body mass in patients with schizophrenia
摘要
Abstract
Objective To investigate the clinical effect of aripiprazole combined with clozapine on glucolipid metabolism , sleep quality and body mass in patients with schizophrenia .Methods Seventy -six pa-tients with schizophrenia were divided into treatment group and control group , each group 38 cases.Control group was given clozapine 400-500 mg・ d -1 .Treatment group was given aripiprazole 30 mg・ d-1 combined clozapine 200-300 mg・ d-1 .The course of treatment was 6 months. The changes of blood glucose and lipid levels , sleep quality , body mass and clinical symptoms were compared in two groups before and after treatment.The clinical efficacy and adverse drug reactions in two groups were observed.Results After treatment, the self-rating scale of sleep ( SRSS ) and pittsburgh sleep quality index ( PSQI ) in treatment group were (15.74 ±3.21), (2.42 ±0.45), significantly lower than (20.45 ±4.67) ,(6.43 ±0.78) in control group(P<0.05).The levels of fasting blood glucose , postprandial 2 h blood glucose, triacylglycerol and cholesterol levels in control group were (5.64 ±0.57), (9.75 ±0.66), (1.57 ±0.18), (5.67 ±0.53) mmol・ L-1, signifi-cantly higher than (4.57 ±0.45), (7.89 ±0.55), (1.03 ±0.13),(4.54 ±0.46) mmol・ L-1 in treatment group ( P <0.05 ) .Body mass and body mass index in control group were ( 68.32 ±4.12 ) kg and ( 26.17 ±4.05 ) kg・ m-2 , significantly higher than (57.56 ±3.63 ) kg and (22.07 ±3.44 ) kg・ m-2 in treatment group ( P<0.05 ) . The total effective rate of treatment group was 92.11%, significantly higher than 76.32%in control group ( P<0.05 ) . The incidence rate of adverse drug reactions in treatment group was 15.79%, obviously lower than 39.47%in control group (P<0.05).Conclusion Aripiprazole combined with clozapine can be beneficial to glucose metabolism and body mass of patients in a stable state in the treatment of patients with schizophrenia , and can improve sleep condition and clinical symptoms of patients , and had less adverse reactions .关键词
阿立哌唑/氯氮平/精神分裂症/糖脂代谢/睡眠Key words
aripiprazole/clozapine/schizophrenia/glucolipid metabolism/sleep分类
医药卫生引用本文复制引用
肖鹏,孙晓花..阿立哌唑联合氯氮平对精神分裂症患者糖脂代谢与睡眠及体重的影响[J].中国临床药理学杂志,2016,32(13):1178-1181,4.基金项目
浙江省医药卫生科技计划基金资助项目 （）
