中国临床药理学杂志2016，Vol.32Issue(14)：1251-1253,3.DOI:10.13699/j.cnki.1001-6821.2016.14.001
丹参川芎嗪联合阿托伐他汀治疗冠心病合并肾损伤的临床研究
Clinical trial on the treatment of combined Danshen Chuanxiongqin and atorvastatin in coronary heart disease with renal injury
摘要
Abstract
Objective To evaluate the effects on correlated biochemical indexes of combined Danshen Chuanxiongqin injection and atorvastatin in coronary heart disease with renal injury .Methods One hundred and fifty-four patients of coronary heart disease with renal injury were randomly divided into A ( n=51 ) , B ( n=52 ) and C ( n=51 ) group. Group A was given atorvastatin 20 mg・ d-1 orally.Group B was given Danshen Chuanxiongqin injection 10 mL・ d -1 intravenous infusion . Group C was given atorvastatin 20 mg・ d-1 orally and Danshen Chuan-xiongqin injection 10 mL・ d-1 .All patients were treated for 14 d.Levels of vascular endothelial growth factor ( VEGF ) , myocyte enhancer factor 2A(MEF2A), retinol binding protein 4(RBP4), serum creatinine(Scr) and blood urea nitrogen ( BUN ) in serum were detected before and after treatment in three groups.Results After treatment, the levels of VEGF and MEF2A in group C were (35.19 ±5.26), (12.39 ±2.12)μg・ mL-1, higher than (27.37 ±3.85),(9.74 ± 1.24)μg・ mL-1 in group A and(25.19 ±4.41),(8.48 ±1.18) in group B(P<0.05).The levels of RBP4, BUN and Scr of patients in group C were (53.72 ±8.26), (73.69 ±16.12), (5.39 ±1.62)mmol・ L-1, had significantly difference with (78.73 ±8.85 ) ,( 89.49 ±19.83 ) , ( 7.14 ±2.24 ) mmol・ L-1 in group A and ( 68.91 ±9.14 ) , (81.48 ±18.18),(6.48 ±2.18)mmol・ L-1 in group B (P<0.05).The main symptoms of adverse drug reactions were chest tightness and chest pain, with no significant difference in three groups (P>0.05).Conclusion Both treat-ments can reduce blood lipid , and improve vascular endothelial function .Meanwhile , Danshen Chuanxiongqin injection play a good role on renal injury, but drug combination showed better efficacy from the change of indexes .关键词
丹参川芎嗪注射液/阿托伐他汀/冠心病合并肾损伤/视黄醇结合蛋白4/血管内皮生长因子/肌细胞增强因子2AKey words
Danshen Chuanxiongqin injection/atorvastatin/coronary heart disease with renal injury/retinol binding protein 4/vascular endothelial growth factor/myocyte enhancer factor 2 A分类
医药卫生引用本文复制引用
王妮,刘伟,毕四锐,齐茗..丹参川芎嗪联合阿托伐他汀治疗冠心病合并肾损伤的临床研究[J].中国临床药理学杂志,2016,32(14):1251-1253,3.基金项目
国家自然科学基金资助项目 （）
