中国临床药理学杂志2016，Vol.32Issue(14)：1254-1256,1282,4.DOI:10.13699/j.cnki.1001-6821.2016.14.002
替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究
Clinical trial of ticagrelor combined with aspirin in the treatment of acute coronary syndrome
摘要
Abstract
Objective To evaluate the clinical efficacy of ticagrelor combined with aspirin in the treatment of acute coronary syndrome . Methods Eighty-four patients with acute coronary syndrome were ran-domly divided into control group (n=42) and treatment group(n=42). Two groups were received aspirin 150 mg oral, qd +clopidogrel bisulfate 300 mg oral, qd for 7 days before operative.Control group was received aspirin 100 mg oral, qd for 6 months after operation.Treatment group was received aspirin 100 mg oral, qd, and ticagrelor 90 mg oral, qd for 6 months.The clinical efficacy , the number of acute myocardial infarction , the levels of ST segment depression , serum cardiac troponin T ( cTnT ) , brain natriuretic peptide (BNP), C reactive protein (CRP), D-dimer, and incidence of adverse drug reactions were compared between two groups.Results After treatment , the total effective rate of treatment group was 95.24%( 40/42 ) , which was significantly higher than that of control group [ 83.33%( 35/42 ) , P<0.05 ] .After treatment , the main observation indexes in treatment and control group: the attack times of acute myocardial infarction were ( 2.02 ±0.23 ) , (4.53 ±0.52) times per week;the attack duration were (2.76 ±0.31), (4.14 ±0.43)min each time; the down level of ST were ( 0.63 ±0.07 ) , ( 1.25 ±0.17 ) mV; cTnT were ( 0.25 ±0.03 ) , ( 1.54 ±0.18 ) ng・ mL-1; BNP were ( 28.43 ±3.02 ) , ( 63.52 ±6.73 ) ng・ L-1; CRP were ( 4.57 ±0.55 ) , ( 8.94 ±0.94 ) mg・ L-1; D-dimer were (59.54 ±61.74), (133.53 ±15.73)ng・ mL-1, and the attack times of acute myocardial infarction , the attack duration, the down level of ST, the levels of cTnT, BNP, CRP and D-dimer in treatment group were significantly lower than those of control group ( P<0.05 ).The adverse drug reactions were based on digestive and nervous system symptoms for two groups.Also, the incidence of adverse drug reactions in control group was 16.67%, treatment group was 7.14%, the difference had statistically significant difference ( P<0.05 ) .Conclusion Ticagrelor combined with aspirin in the treatment of acute coronary syndrome was effective and safety .关键词
替格瑞洛/阿司匹林/急性冠状动脉综合征/临床疗效/安全性Key words
ticagrelor/aspirin/acute coronary syndrome/safety分类
医药卫生引用本文复制引用
贾珠银,杨建敏..替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256,1282,4.基金项目
浙江省医药卫生一般研究计划基金资助项目 （）
