中国临床药理学杂志2016，Vol.32Issue(14)：1276-1278,3.DOI:10.13699/j.cnki.1001-6821.2016.14.008
α－硫辛酸治疗早期糖尿病肾病患者的临床研究
Clinical trial ofα-lipoic acid in the treatment of patients with early diabetic nephropathy
摘要
Abstract
Objective To investigate the clinical effect of α-lipoic acid in the treatment of patients with early diabetic nephropathy and its effect on urinary albumin excretion rate and plasma endothelin -1. Methods A total of 80 patients with early diabetic nephropathy were di-vided into control group and treatment group based on different treatment regimens, 40 patients in each group.Patients in control group were given conventional treatment .Patients in treatment group were given intrave-nous infusionα-lipoic acid 450 mL daily.All patients were treated for 2 weeks.Clinical efficacy of two groups was compared .The fasting blood glucose , 2 h postprandial blood glucose , systolic and diastolic blood pressure , serum superoxide dismutase ( SOD ) and malondialdehyde ( MDA ) in two groups were observed before and after treatment . Results After treatment , the fasting blood glucose , 2 h postprandial blood glucose , systolic and diastolic blood pressure in treatment group were ( 5.72 ±1.23 ) mmol・ L-1 , ( 9.55 ±1.58 ) mmol・ L-1 , (117.09 ±5.77 ) mmHg, ( 84.10 ±5.69 ) mmHg, significantly lower than ( 6.42 ±1.29 ) mmol・ L-1 , ( 10.59 ±1.66 ) mmol・ L-1 , (125.97 ±7.82) mmHg, (90.98 ±5.61) mmHg in control group (P<0.05).After treatment, serum SOD in treat-ment group was ( 94.68 ±6.31 ) U・ mg-1 , significantly higher than ( 64.38 ±4.54 ) U・ mg -1 in control group (P<0.05).The MDA in treatment group was (2.63 ±0.49)mmol・ L-1, significantly lower than (3.98 ±0.16) mmol・ L-1 in control group ( P<0.05 ) .After treatment , urinary albumin excretion rate and plasma endothelin 1 in treatment group were ( 32.15 ±5.17 ) , ( 20.43 ±2.11 ) ng・ L-1 , significantly lower than ( 77.95 ±10.79 )μg・ min -1 , (59.15 ±6.44 ) ng・ L-1 in control group ( P <0.05 ) .There was no adverse drug reactions in two groups.Conclusion The clinical efficiency of α-lipoic acid on patients with early diabetic nephropathy was signifi-cant, can significantly decreased the levels of urinary albumin excretion rate and plasma endothelin -1.关键词
α-硫辛酸/糖尿病肾病/尿微量白蛋白排泄率/血浆内皮素-1Key words
α-lipoic acid/diabetic nephropathy/urinary albumin excretion rate/plasma endothelin-1分类
医药卫生引用本文复制引用
袁晓英,王晓娜,江蓓..α－硫辛酸治疗早期糖尿病肾病患者的临床研究[J].中国临床药理学杂志,2016,32(14):1276-1278,3.基金项目
山东省自然科学基金资助项目 （）
